急性ST段抬高型心肌梗死入院即刻单核细胞与淋巴细胞比值与心血管事件相关性研究

发布时间：2018-06-20 13:54

本文选题：ST段抬高型心肌梗死 + 单核淋巴细胞比值　；参考：《中国实用内科杂志》2016年01期

【摘要】：目的探讨入院即刻单核细胞与淋巴细胞比值(MLR)与接受直接经皮冠状动脉介入(PCI)治疗的急性ST段抬高型心肌梗死(STEMI)患者发病后主要不良心血管事件(MACEs)的相关性。方法连续入选2014年武警后勤学院附属医院心脏中心接受直接PCI治疗的STEMI患者100例,记录发病20个月内MACEs的发生情况,并采用Cox回归模型,分析入院即刻MLR、既往病史、药物治疗等因素与MACEs的关系。结果在武警后勤学院心脏中心连续纳入的100例STEMI患者中,随访20个月后共有25例患者发生了MACEs(25%),多变量Cox回归分析显示入院MLR(OR 1.469,95%CI 1.081~1.997,P=0.014)与MACEs的发生显著相关。在校正了传统危险因素后,MLR仍是MACEs发生的独立危险因素(OR 1.491,95%CI 1.104~2.011,P=0.009)。以MLR中位数0.28为界,将100例患者分为2组,Kaplan-Meier生存曲线分析显示MLR0.28组患者在20个月随访结束时MACEs的发生率高于MLR0.28组(P=0.038)。结论 STEMI患者入院即刻的MLR是与MACEs发生密切相关的独立危险因素。
[Abstract]:Objective to investigate the correlation between MLR (monocyte to lymphocyte ratio) immediately after admission and major adverse cardiovascular events (MACEs) in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with direct percutaneous coronary intervention (PCI). Methods 100 STEMI patients who received direct PCI treatment in the cardiac center of the affiliated Hospital of Armed Police Logistics College in 2014 were selected to record the occurrence of MACEs within 20 months of onset. The Cox regression model was used to analyze MLRs and past medical history immediately after admission. The relationship between drug therapy and MACEs. Results among 100 consecutive STEMI patients enrolled in the heart center of the Armed Police Logistics College, 25 cases of MACEs were diagnosed after 20 months follow-up. Multivariate Cox regression analysis showed that there was a significant correlation between the incidence of MACEs and the incidence of MACEs. The multivariate Cox regression analysis showed that there was a significant correlation between the admission MLROR 1.46995 CI 1.081 and 1.997P0. 014). After adjusting for traditional risk factors, MLR is still an independent risk factor for the occurrence of MACEs. According to the median MLR of 0.28, 100 patients were divided into two groups: Kaplan-Meier survival curve analysis showed that the incidence of MACEs in MLR 0.28 group was higher than that in MLR 0.28 group at the end of 20 months follow-up. Conclusion MLR of STEMI patients at admission is an independent risk factor associated with MACEs.
【作者单位】：武警后勤学院附属医院心脏中心武警部队心血管病研究所;天津市心血管重塑与靶器官损伤重点实验室;
【基金】：国家自然科学基金(81170238,81570335) 天津市心血管重塑与靶器官损伤重点实验室开放基金(TJC1404,TJC1408)
【分类号】：R542.22

【相似文献】