急性脑梗死患者血清sCD40L、YKL-40水平变化

发布时间：2018-06-20 20:13

本文选题：急性脑梗死 + 可溶性CD配体　；参考：《山东医药》2016年15期

【摘要】：目的观察急性脑梗死(ACI)患者血清可溶性CD40配体(s CD40L)、人类软骨糖蛋白3(YKL-40)水平变化,并探讨其意义。方法 ACI患者90例(脑梗死组),根据梗死体积分为大梗死者14例、中梗死者31例、小梗死者45例,根据神经功能缺损评分分为重度损伤者15例、中度损伤者36例、轻度损伤者39例,另选同期健康体检者30例作为对照组。采用ELISA法检测血清s CD40L、YKL-40,Pearson相关分析法分析两指标的相关性。结果与对照组比较,脑梗死组s CD40L、YKL-40水平升高(P均0.05);脑梗死组不同梗死体积者s CD40L、YKL-40水平两两比较,脑梗死组不同神经功能损伤者s CD40L、YKL-40水平两两比较,P均0.05。脑梗死组血清s CD40L与YKL-40水平呈正相关(r=0.78,P0.01)。结论 ACI患者血清s CD40L、YKL-40水平升高,且随梗死体积和神经功能缺损程度变化而变化,检测两指标有助于脑梗死的病情评估。
[Abstract]:Objective to observe the changes of serum soluble CD40 ligand and human chondroglycoprotein 3- (YKL-40) in patients with acute cerebral infarction (ACI) and to explore its significance. Methods 90 patients with ACI were divided into three groups according to infarct volume: 14 cases of large infarction, 31 cases of middle infarction, 45 cases of small infarction, 15 cases of severe injury and 36 cases of moderate injury according to neurological deficit score. 39 cases of mild injury and 30 cases of health examination were selected as control group. The correlation between the two indexes was analyzed by Elisa method. Results compared with the control group, the levels of sCD40LnYKL-40 in cerebral infarction group were significantly higher than those in control group (P < 0.05), and in patients with different infarct volumes, the levels of sCD40L and YKL-40 were significantly higher than those in control group (P < 0.01). The levels of sCD40LtYKL-40 in patients with different neurological function in cerebral infarction group were significantly higher than those in control group (P < 0.05). There was a positive correlation between serum sCD40L and YKL-40 levels in patients with cerebral infarction. Conclusion the level of serum sCD40LnyKL-40 in patients with ACI is increased and changes with the changes of infarct volume and the degree of neurological deficit. The detection of two indexes is helpful to the assessment of cerebral infarction.
【作者单位】：皖北煤电集团总医院;
【分类号】：R743.3

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