大株红景天注射液联合长春西汀注射液治疗急性大面积脑梗死的临床观察

发布时间：2018-07-06 19:58

本文选题：急性大面积脑梗死 + 大株红景天注射液　；参考：《中国药房》2017年32期

【摘要】：目的:考察大株红景天注射液联合长春西汀注射液对急性大面积脑梗死患者的临床疗效、血液流变学指标及血清一氧化氮合酶(NOS)的影响。方法:选取2014年1月-2016年6月我院收治的大面积脑梗死患者60例作为研究对象。按照随机数字表法将患者分为对照组和试验组,各30例。对照组患者给予胞二磷胆碱注射液0.5 g,ivgtt,qd;试验组在此基础上给予长春西汀注射液20 mg加至0.9%氯化钠注射液250 m L中,ivgtt,qd;间隔1 h后冲管,给予大株红景天注射液10 m L加至0.9%氯化钠注射液250 m L中,ivgtt,qd,连续给药14 d。观察两组患者的临床疗效和安全性,以及治疗前后血液流变学指标和NOS水平。结果:试验组患者临床总有效率(83.33%)显著高于对照组(50.00%),差异有统计学意义(P0.05)。治疗前,两组患者血液流变学指标及血清NOS水平比较,差异均无统计学意义(P0.05)。治疗后,两组患者血液流变学指标均显著降低,且试验组显著低于对照组;两组患者的血清NOS水平均显著增加,且试验组显著高于对照组,差异均有统计学意义(P0.05)。两组患者均未见明显的不良反应发生。结论:大株红景天注射液联合长春西汀注射液治疗急性大面积脑梗死的疗效显著,可减轻血液黏度,增加血流灌注,且安全性较高。
[Abstract]:Objective: to investigate the clinical efficacy, hemorheological parameters and serum nitric oxide synthase (NOS) in patients with acute large area cerebral infarction treated with RDJI combined with vinpocetine injection. Methods: from January 2014 to June 2016, 60 patients with massive cerebral infarction were selected. The patients were divided into control group and experimental group with 30 cases each. The patients in the control group were given citicoline injection 0.5 g / iv QD, the experimental group was treated with vinpocetine injection 20 mg / L to 0.9% sodium chloride injection 250 mL iv gttttqd, and the tube was flushed after 1 hour interval, and the control group was treated with vinpocetine injection (20 mg / ml) and 0.9% sodium chloride injection (250 mL / ml). Large strain Rhodiola injection (10 mL) was added to 0.9% sodium chloride injection (250 mL) for 14 days. The clinical efficacy and safety, hemorheological index and NOS level before and after treatment were observed. Results: the total effective rate in the trial group (83.33%) was significantly higher than that in the control group (50.00%), the difference was statistically significant (P0.05). Before treatment, there was no significant difference in hemorheological indexes and serum NOS levels between the two groups (P0.05). After treatment, the hemorheological indexes of the two groups were significantly decreased, and the experimental group was significantly lower than the control group; the serum NOS levels of the two groups were significantly increased, and the experimental group was significantly higher than the control group, the difference was statistically significant (P0.05). No significant adverse reactions occurred in both groups. Conclusion: large strain Rhodiola injection combined with vinpocetine injection is effective in the treatment of acute large area cerebral infarction, which can reduce blood viscosity and increase blood perfusion.
【作者单位】：河北北方医学院附属第一医院神经外科;河北北方医学院附属第一医院药学部;
【基金】：张家口市科学技术与发展计划自筹经费项目(No.1421120D)
【分类号】：R743.33

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