血必净注射液与氢化可的松联合治疗的脓毒症MODS患者血清HLA-DR和LPO水平变化

发布时间：2018-07-10 01:51

本文选题：血必净注射液 + 氢化可的松　；参考：《山东医药》2016年23期

【摘要】：目的观察脓毒症多脏器功能障碍综合征(MODS)患者血必净注射液联合氢化可的松治疗前后血清单核细胞表面人类白细胞抗原DR位点(HLA-DR)和过氧化脂质(LPO)水平变化情况。方法将236例脓毒症MODS患者随机分为对照组(78例)、观察组1(78例)、观察组2(80例),对照组给予综合治疗,观察组1在对照组基础上应用血必净注射液治疗,观察组2在观察组1治疗基础上应用氢化可的松治疗。检测各组治疗前及治疗后第1、3和7天血清HLA-DR和LPO。比较各组治疗7 d内病死率。结果治疗后第3、7天,与对照组相比,观察组1、观察组2血清HLA-DR水平高,LPO水平低(P均0.05)。治疗后第3、7天,与观察组1相比,观察组2血清HLA-DR水平高,LPO水平低(P均0.05)。对照组死亡48例,观察组1死亡32例,观察组2死亡20例,观察组1、观察组2与对照组相比,观察组2与观察组1相比,P均0.05。结论脓毒症MODS患者血必净注射液联合低剂量氢化可的松治疗后血清HLA-DR水平升高,LPO水平降低。
[Abstract]:Objective to observe the changes of HLA-DR and LPO on the surface of monocytes in patients with septic multiple organ dysfunction syndrome (mods) before and after treatment with Xuebijing injection and hydrocortisone. Methods 236 patients with sepsis mods were randomly divided into control group (78 cases), observation group 1 (78 cases) and observation group 2 (80 cases). Observation group 2 was treated with hydrocortisone on the basis of observation group 1. Serum HLA-DR and LPO were measured before treatment and on the 1st and 7th day after treatment. The mortality of each group within 7 days was compared. Results compared with the control group, the serum HLA-DR level in the observation group 1 was higher than that in the control group (P 0.05), and the serum HLA-DR level in the observation group 2 was higher than that in the control group (P 0.05). On the 3rd day after treatment, the serum HLA-DR level in the observation group was higher than that in the observation group 1 (P 0.05). 48 cases died in the control group, 32 cases died in the observation group 1, 20 cases died in the observation group 2, the observation group 1, the observation group 2 compared with the control group, the observation group 2 compared with the observation group 1 (P 0.05). Conclusion the serum HLA-DR level in septic mods patients increased and LPO decreased after treatment with Xuebijing injection and low dose hydrocortisone.
【作者单位】：天津市第五中心医院;华北理工大学附属医院;
【基金】：河北省医学科学研究重点课题(ZD20140500)
【分类号】：R459.7

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