2007-2011年烧伤患者细菌分布及耐药性分析

发布时间：2018-07-13 18:34

【摘要】：目的对5年笔者单位烧伤患者细菌分布及耐药性变化进行回顾性分析,为今后防治感染提供参考。方法收集2007年1月-2011年12月笔者单位烧伤病房537例烧伤患者各类标本中分离的细菌,对细菌分布及耐药性情况进行分析。结果革兰阴性杆菌共637株、占62.76%,检出率呈上升趋势；革兰阳性球菌共323株、占31.82%,检出率呈下降趋势。检出率由高到低前8位的细菌依次是：铜绿假单胞菌、金黄色葡萄球菌、鲍氏不动杆菌、肺炎克雷伯杆菌、大肠埃希菌、阴沟肠杆菌、凝固酶阴性葡萄球菌、奇异变形杆菌。铜绿假单胞菌对头孢他啶、头孢哌酮/舒巴坦、亚胺培南耐药率分别为34.27%、40.88%、26.29%。鲍氏不动杆菌除对头孢哌酮/舒巴坦较敏感外(耐药率为29.51%),对其他抗生素广泛耐药。多重耐药/泛耐药铜绿假单胞菌(multidrug-resistant/pandrug-resistant Pesudomonas aemginosa, MDR/PDR-PA)及耐碳青霉烯类/泛耐药鲍氏不动杆菌(Carbapenems-resistant/pandrug-resistant Acinetobacter baumannii, CR/PDR-AB)检出率呈明显上升趋势。金黄色葡萄球菌以多重耐药的MRSA为主,其对万古霉素、利奈唑胺、替考拉宁的耐药率分别为为0、0、5.71%。MRSA检出率呈下降趋势。结论笔者单位主要细菌多重耐药/泛耐药现象日益严重,临床应予以重视并合理用药。
[Abstract]:Objective to analyze the changes of bacterial distribution and drug resistance in burn patients for 5 years and to provide reference for prevention and treatment of infection in the future. Methods the bacteria isolated from 537 burn patients from January 2007 to December 2011 were collected and the distribution and drug resistance of bacteria were analyzed. Results there were 637 gram-negative bacilli (62.76), and 323 gram-positive cocci (31.82%) showed a decreasing trend. Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, coagulase negative Staphylococcus, Proteus mirabilis were the first 8 bacteria in the detection rate. The resistance rates of Pseudomonas aeruginosa to ceftazidime, cefoperazone / sulbactam and imipenem were 34.27%, 40.88% and 26.29%, respectively. Acinetobacter baumannii was sensitive to cefoperazone / sulbactam (29.51%) and widely resistant to other antibiotics. The detection rates of multidrug-resistant/pandrug-resistant Pesudomonas aemginosa (MDR / PDR-PA) and Carbapenems-resistant / pan-resistant Acinetobacter baumannii (CRPDR-AB) increased significantly. MRSA was mainly multidrug resistant staphylococcus aureus. The drug resistance rates of MRSA to vancomycin, linazolamine and teicoplanin were 0 0, 5. 71. MRSA respectively. The positive rate of MRSA decreased. Conclusion the phenomenon of multidrug resistance / pan-resistance of the main bacteria is becoming more and more serious, which should be paid more attention to and used rationally in clinic.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R644

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