白细胞计数与急性非ST段抬高型心肌梗死患者预后相关关系的研究

发布时间：2018-07-25 06:01

【摘要】：目的探索白细胞计数对急性非ST段抬高型心肌梗死(non-ST-segment elevation myocardial infarction,NSTEMI)患者预后的预测价值。方法回顾分析了198例急性NSTEMI患者的随访资料。入院时即刻检测血白细胞计数。研究的主要终点是死亡、再发心肌梗死、再次血运重建和脑卒中。使用多因素回归分析影响预后的因素。结果 2组患者基线资料除入院时心率和肌酸激酶同工酶外差异均无统计学意义,白细胞计数11.0×109/L组住院期间和出院后6个月主要不良心脑血管事件发生率明显高于白细胞计数≤11.0×109/L组(25.5%vs 10.4%,P=0.006;18.4%vs 5.2%,P=0.004),Logistics多因素回归分析显示白细胞计数11.0×10~9/L是住院期间主要不良心脑血管事件的独立危险因素(OR=2.942,95%CI:1.333~6.495,P=0.008),Cox多因素回归分析显示白细胞计数11.0×10~9/L是出院后6个月主要不良心脑血管事件的独立危险因素(RR=3.767,95%CI:1.406~10.089,P=0.008)。结论白细胞计数升高是急性NSTEMI患者心脑血管事件发生的独立危险因素。
[Abstract]:Objective to explore the prognostic value of leukocyte count in patients with acute non-St segment elevation myocardial infarction (non-ST-segment elevation myocardial segment elevation NSTEMI). Methods the follow-up data of 198 patients with acute NSTEMI were retrospectively analyzed. The white blood cell count was measured immediately after admission. The main endpoints of the study were death, recurrent myocardial infarction, re-revascularization and stroke. Multivariate regression analysis was used to analyze the prognostic factors. Results there was no significant difference in baseline data except heart rate and creatine kinase isoenzyme between the two groups. The incidence of major adverse cardiovascular and cerebrovascular events during hospitalization and 6 months after discharge was significantly higher in the 25.5%vs 10.4 脳 10 9 / L group than in the 25.5%vs 10.4 脳 10 9 / L group (25.5%vs 10.4 脳 10 9 / L). Logistic multivariate regression analysis showed that the white blood cell count of 11.0 脳 10 9 / L was the main adverse event during hospitalization. The Cox multivariate regression analysis showed that the white blood cell count (11.0 脳 10 ~ 9 / L) was the independent risk factor of major adverse cardiovascular and cerebrovascular events at 6 months after discharge (RRN 3.767 ~ 95% CI 1.40610.089P 0.008). Conclusion elevated leukocyte count is an independent risk factor for cardiovascular and cerebrovascular events in patients with acute NSTEMI.
【作者单位】：首都医科大学附属北京天坛医院心内科;北京市门头沟区医院心内科;
【分类号】：R542.22

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