急性颅脑损伤后胰岛素抵抗、血清IL-6及IL-10的相关性研究

发布时间：2018-07-28 07:32

【摘要】：目的分析急性颅脑损伤不同程度不同时间段患者血糖、胰岛素水平关系及血清白细胞介素6（IL-6）和白介素10（IL-10）的含量变化及临床意义。方法106例急性颅脑损伤患者按入院时GCS评分分为轻度、中度和重度三组，分别于伤后1d、2d、3d、4d、5d测定空腹血糖、血清胰岛素值并计算胰岛素抵抗指数（HOMA-IR），分析急性颅脑损伤程度与HOMA-IR之间关系；在采用酶联免疫吸附（ELISA）法测定血清IL-6、IL-10含量，根据IL-6、IL-10的动态变化，分析急性颅脑损伤程度与血清IL-6、IL-10含量之间关系。结果不同程度的急性颅脑损伤患者血糖、胰岛素水平及HOMA-IR有显著差异（Ｐ0.01,Ｐ0.05），血糖、血清胰岛素和HOMA-IR越高，急性颅脑损伤的程度越重，同时血清IL-6含量在伤后高于对照组（P0.05），而在重型颅脑损伤中增高较轻型和中型损伤更为明显（P0.05）。不同程度的急性颅脑损伤患者血清IL-10含量在伤后高于对照组（P0.05），，而在重型颅脑损伤中增高较轻型和中型损伤更为明显（P0.05）结论空腹血糖值、HOMA-IR及血清IL-6、IL-10含量与急性颅脑损伤程度存在相关性，可作为评估急性颅脑损伤严重程度及预后的一个客观指标。
[Abstract]:Objective to analyze the relationship between blood glucose, insulin and serum interleukin 6 (IL-6) and interleukin 10 (IL-10) levels in patients with acute craniocerebral injury. Methods 106 patients with acute craniocerebral injury were divided into mild, moderate and severe groups according to the GCS score at admission. Fasting blood glucose levels were measured at 2 days, 3 days, 4 days and 5 days after injury, respectively. Serum insulin level and insulin resistance index (HOMA-IR) were calculated to analyze the relationship between the degree of acute craniocerebral injury and HOMA-IR, the level of IL-10 in serum was determined by enzyme-linked immunosorbent assay (ELISA), and the dynamic changes of IL-10 were observed according to the level of IL-6. To analyze the relationship between the degree of acute craniocerebral injury and the level of IL-10 in serum. Results there were significant differences in blood glucose, insulin level and HOMA-IR in patients with acute craniocerebral injury (P0.01P 0.05). The higher the blood glucose, serum insulin and HOMA-IR were, the more severe the acute craniocerebral injury was. At the same time, the level of serum IL-6 was higher after injury than that in control group (P0.05), but it was higher in severe craniocerebral injury than that in mild and moderate injury (P0.05). The level of serum IL-10 in patients with acute craniocerebral injury of different degrees was higher than that in control group (P0.05), but it was significantly higher in severe craniocerebral injury than that in mild and moderate injury (P0.05). Conclusion fasting blood glucose level, HOMA-IR and serum IL-6 IL-10 levels in patients with acute craniocerebral injury are significantly higher than those in patients with acute craniocerebral injury. There is a correlation between the degree of injury, It can be used as an objective index to evaluate the severity and prognosis of acute craniocerebral injury.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R651.15

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