同型半胱氨酸水平与急性脑梗死病变程度的相关性

发布时间：2018-07-28 10:33

【摘要】：目的探讨同型半胱氨酸(Hcy)水平与急性脑梗死病变程度的相关性。方法选择急性脑梗死患者72例作为观察组,同期缺血性脑血管病患者72例作为对照组,两组均进行血清Hcy的检测、颈动脉内膜中层厚度(IMT)的超声测定与临床资料的调查与分析。结果观察组血清Hcy水平明显高于对照组(P0.05),且观察组高Hcy发生率更高(P0.05)。观察组IMT值,IMT增厚率明显高于对照组(P0.05)。观察组神经功能缺损(NIHSS)评分明显高于对照组(P0.05),同时神经功能障碍情况也明显差于对照组(P0.05)。直线相关分析显示血清Hcy水平与IMT和NIHSS评分呈正相关(r=0.310,0.624,P0.05)。结论急性脑梗死患者伴有Hcy水平升高,也表现出IMT增厚和神经功能障碍,三者可互相影响,能有效反映急性脑梗死病变程度的变化。
[Abstract]:Objective to investigate the correlation between the level of homocysteine (Hcy) and the severity of acute cerebral infarction. Methods 72 patients with acute cerebral infarction and 72 patients with ischemic cerebrovascular disease were selected as the observation group and the control group respectively. The serum Hcy, carotid intima-media thickness (IMT) and clinical data were measured and analyzed in both groups. Results the serum Hcy level in the observation group was significantly higher than that in the control group (P0.05), and the incidence of high Hcy in the observation group was higher than that in the control group (P0.05). The thickening rate of IMT in the observation group was significantly higher than that in the control group (P0.05). The (NIHSS) score of nerve function defect in the observation group was significantly higher than that in the control group (P0.05), and the neurological dysfunction in the observation group was also significantly worse than that in the control group (P0.05). Linear correlation analysis showed that serum Hcy level was positively correlated with IMT and NIHSS score (r = 0.310 卤0.624 P 0.05). Conclusion the patients with acute cerebral infarction have higher Hcy level, as well as IMT thickening and neurological dysfunction. The three factors can influence each other and can effectively reflect the changes of the severity of acute cerebral infarction.
【作者单位】：遵化市人民医院神经内科;遵化市人民医院检验科;遵化市人民医院心内科;河北医科大学第二医院;
【基金】：河北省卫生厅课题(No.20130472)
【分类号】：R743.33

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