急性脑梗死患者血浆巯基丙酮酸硫基转移酶及β-淀粉样蛋白42的水平及其临床意义

发布时间：2018-08-12 10:36

【摘要】：目的探讨脑梗死(cerebral infarction,CI)患者急性期血浆巯基丙酮酸硫基转移酶(3-mercaptopyruvate sulfurtransferase,3-MST)及β-淀粉样蛋白42(β-amyloid peptide 42,Aβ42)水平及其与脑梗死体积、神经功能缺损程度的关系。方法抽取52例急性期CI患者及35例健康人血浆标本,采用ELISA检测其3-MST及Aβ42水平,分析2组人群血浆3-MST及Aβ42水平的差异及其与脑梗死的关系。结果 CI患者组血浆3-MST水平较健康对照组水平明显降低[(3.67±0.29)vs(4.98±0.30)ng/m L,P0.05],CI患者组血浆Aβ42水平较健康对照组水平显著增高[(44.52±2.92)vs(15.77±1.71 pg/m L),P0.01]。急性CI患者中,血浆3-MST水平随脑梗死体积增大和NIHSS评分增加而降低;血浆Aβ42水平随脑梗死体积增大及NIHSS评分增加而升高。结论脑梗死患者急性期的血浆3-MST水平明显降低、Aβ42水平显著增高,其变化与脑梗死患者神经功能缺损程度及梗死灶体积有关。
[Abstract]:Objective to investigate the relationship between plasma 3-mercaptopyruvate sulfurtransferase 3-MST and 尾 -amyloid peptide 42 A 尾 42 in patients with acute cerebral infarction (cerebral infarction CI). Methods the levels of 3-MST and A 尾 42 were measured by ELISA in 52 patients with acute CI and 35 healthy controls. The difference of plasma 3-MST and A 尾 42 levels and their relationship with cerebral infarction were analyzed. Results the plasma 3-MST level in CI group was significantly lower than that in healthy control group [(3.67 卤0.29) vs (4.98 卤0.30) ng/m / L] the plasma A 尾 42 level in CI group was significantly higher than that in healthy control group [(44.52 卤2.92) vs (15.77 卤1.71 pg/m L) P 0.01]. In patients with acute CI, the plasma 3-MST level decreased with the increase of cerebral infarction volume and NIHSS score, and the plasma A 尾 42 level increased with the increase of cerebral infarction volume and NIHSS score. Conclusion the level of plasma 3-MST in patients with acute cerebral infarction is significantly lower than that in patients with acute cerebral infarction. The changes of plasma 3-MST 尾 42 level are related to the degree of neurological deficit and the volume of infarct focus in patients with cerebral infarction.
【作者单位】：重庆医科大学附属第一医院神经内科;
【基金】：国家自然科学基金面上项目(81271222)~~
【分类号】：R743.33

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