缺血性脑卒中急性期血清缺血修饰蛋白、脂肪酸结合蛋白水平的变化及与神经功能缺损程度的关系

发布时间：2018-08-16 15:11

【摘要】：目的探讨缺血性脑卒中急性期血清缺血修饰蛋白(IMA)、脂肪酸结合蛋白水平的变化及与神经功能缺损程度的关系。方法随机选取2013年1月至2015年7月缺血性脑卒中患者115例作为研究组,其中急性期60例,稳定期55例,同期选取健康体检者50例作为对照组,采用游离钴比色法检测IMA水平,双抗夹心法检测脂肪酸结合蛋白水平,依据美国国立卫生研究院脑卒中量表(NIHSS)标准评估神经功能缺损程度。结果缺血性脑卒中急性期血清IMA、脂肪酸结合蛋白水平与NIHSS评分均明显高于稳定期与对照组(P0.05),稳定期均明显高于对照组(P0.05)。缺血性脑卒中急性期血清IMA、脂肪酸结合蛋白阳性率均明显高于稳定期与对照组(P0.05),且稳定期均明显高于对照组(P0.05)。Pearson相关性分析显示,血清IMA、脂肪酸结合蛋白与NIHSS评分呈明显正相关(r=0.521,0.541,P0.05)。结论血清IMA、脂肪酸结合蛋白水平在缺血性脑卒中急性期中显著增高,且与神经功能缺损程度具有紧密的关系,两者可作为神经功能缺损程度的重要评估指标。
[Abstract]:Objective to investigate the changes of fatty acid binding protein (IMA),) in serum ischemic modified protein (IMA),) and its relationship with neurological impairment in acute ischemic stroke. Methods from January 2013 to July 2015, 115 patients with ischemic stroke were randomly selected as study group, including 60 cases in acute phase, 55 cases in stable stage and 50 cases as control group. Free cobalt colorimetry was used to detect the level of IMA. The level of fatty acid binding protein was detected by double antibody sandwich method, and the degree of neurological impairment was evaluated according to the (NIHSS) criteria of the National Institutes of Health Stroke scale. Results the levels of serum NIHSS, fatty acid binding protein and NIHSS in the acute phase of ischemic stroke were significantly higher than those in the stable phase and the control group (P0.05), and those in the stable phase were significantly higher than those in the control group (P0.05). The positive rates of serum NIHSS and fatty acid binding protein in acute phase of ischemic stroke were significantly higher than those in stable phase and control group (P0.05). Pearson correlation analysis showed that there was a significant positive correlation between serum IMA, fatty acid binding protein and NIHSS score (r = 0.521 卤0.541p0.05). Conclusion the levels of serum IMA and fatty acid binding protein are significantly increased in acute phase of ischemic stroke and are closely related to the degree of neurological impairment. They can be used as an important index to evaluate the degree of neurological impairment.
【作者单位】：东南大学医学院附属江阴医院神经内科;
【分类号】：R743.33

【相似文献】