Simplified psychometric hepatic encephalopathy scale Liver c

  本文关键词：简化版肝性脑病心理测试评分量表对轻微型肝性脑病的诊断价值，由笔耕文化传播整理发布。

简化版肝性脑病心理测试评分量表对轻微型肝性脑病的诊断价值

Diagnostic value of a simplified psychometric hepatic encephalopathy scale for minimal hepatic encephalopathy

[1] [2] [3] [4] [5]

Chen Lei, Zhao Jiangming, Wu Yuanbo, Li Wenting, Wu A imei. （Department of Neurology, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China）

[1]安徽医科大学附属省立医院神经内科,合肥230001; [2]安徽医科大学附属省立医院感染科,合肥230001; [3]安徽医科大学附属合肥市第二人民医院神经内科,合肥230011

文章摘要：目的 探讨简化版肝性脑病心理测试评分（SPHES）量表对轻微型肝性脑病（MHE）的诊断及显性肝性脑病（OHE）的预测价值. 方法 选择安徽医科大学附属省立医院感染科自2012年10月至2013年6月收治的均无OHE的乙肝肝硬化患者70例作为试验组,以同期健康体检中心志愿者72例作为健康对照组,分别完成肝性脑病心理测试评分（PHES）量表.以健康对照组建立PHES系统5个测试项目的预期正常参考值公式,应用Logistic回归分析逐步缩减PHES的子量表个数得到SPHES量表.对试验组患者完成SPHES量表并随访1年,筛查MHE的患病率和OHE的发生. 结果 PHES量表易受年龄和教育年限的影响.应用PHES和SPHES量表筛查试验组患者MHE的患病率,分别为31/70、29/70,比较差异无统计学意义（P＞0.05）;21例肝硬化患者进展为OHE,PHES量表、SPHES量表诊断为MHE的患者OHE发生率比较差异无统计学意义（P＞0.05）.结论 SPHES量表在诊断MHE和预测OHE的发生方面与PHES量表具有同等价值,且更简便,适于临床筛查.

Abstr：Objective The psychometric hepatic encephalopathy scale （PHES）,including five psychometric tests,is a standard for the diagnosis of minimal hepatic encephalopathy （MHE） and enjoys predictive value of overt hepatic encephalopathy （OHE）.We investigate whether a simplified PHES is as useful as the whole PHES.Methods Seventy consecutive hepatitis B cirrhotic patients without OHE,admitted to our hospital from October 2012 to June 2013,and other 72 healthy volunteers were chosen in our study.PHES was performed in both groups.Expected normal reference value formula were established based on the 5 psychometric tests in healthy controls,and backward logistic regression was performed by eliminating stepwise variables of PHES to get a simplified PHES （SPHES）.Then,SPHES was performed on the 70 patients and followed up for a year to detect the prevalence rate of MHE and OHE.Results PHES was easily influenced by age and educational level.In patients with liver cirrhosis,44.29% patients （31/70） had MHE based on PHES and 41.43% （9/70） had MHE based on SPHES,without significant differences （P〉0.05）.According to the follow-up study,21 patients developed OHE; the number of developing OHE showed no significant difference between MHE patients dignosed by PHES and SPHES （P〉0.05）.Conclusion SPHES is as good as PHES in diagnosing MHE and predicting the occurrence of OHE,which consumes less time and is more suitable for clinical screening.

文章关键词：

Keyword：:Simplified psychometric hepatic encephalopathy scale Liver cirrhosis Minimal hepatic encephalopathy Overt hepatic encephalopathy

课题项目：安徽省自然科学青年基金（11040606Q09）;安徽医科大学附属省立医院三新项目

作者信息：会员可见

  本文关键词：简化版肝性脑病心理测试评分量表对轻微型肝性脑病的诊断价值，由笔耕文化传播整理发布。