慢性肌筋膜激痛点大鼠模型的剪切波弹性模量研究

发布时间：2018-08-31 12:09

【摘要】：目的研究弹性超声在大鼠肌筋膜激痛点鉴定中的应用价值,为肌筋膜疼痛综合征等疾病的诊断研究提供依据。方法 24只雄性SD大鼠(7周龄),随机分成对照组和模型组,模型组采取钝性打击结合离心运动的实验方法对其进行连续8周的干预,造模结束后,模型组与对照组均正常饲养4周,12周结束后通过电生理检测技术进行模型鉴定,并对激痛点行超声检查,检测激痛点的剪切波弹性模量,进一步分析比较组间差异。结果模型组大鼠股内侧肌肌电表现出异常自发电位,证明激痛点的存在;激痛点病灶区的剪切波弹性模量明显高于临近区(P0.05),且模型组激痛点病灶区与临近区组织弹性模量均高于对照组。结论剪切波弹性模量测量方法可以量化激痛点的硬度特征,且提示激痛点病灶区硬度显著增大,可为临床触诊提供客观依据,实现对病灶区与临近区的有效鉴别,为鉴定激痛点动物模型提供了一种新方法,对于肌筋膜激痛点相关疾病的临床诊断与疗效评价具有重要的研究与应用价值。
[Abstract]:Objective to study the value of elastic ultrasound in the identification of myofascial excitatory pain points in rats, and to provide evidence for the diagnosis of myofascial pain syndrome and other diseases. Methods Twenty-four male SD rats (7 weeks old) were randomly divided into two groups: the control group and the model group. The rats in the model group were treated with blunt blow and centrifugal exercise for 8 weeks. The model was identified by electrophysiological examination after 4 weeks and 12 weeks of normal feeding in the model group and the control group. The shear wave elastic modulus of the excitatory pain point was detected by ultrasonic examination, and the difference between the groups was analyzed. Results in the model group, the medial femoris myoelectric activity showed abnormal spontaneous potential, which proved the existence of excitatory pain points. The shear wave elastic modulus of the focal area of the excitatory pain point was significantly higher than that of the adjacent area (P0.05), and the elastic modulus of the lesion area and adjacent area of the model group were higher than that of the control group. Conclusion the measurement method of shear wave elastic modulus can quantify the hardness characteristics of the excitatory pain point, and it indicates that the hardness of the focal area increases significantly, which can provide an objective basis for clinical palpation, and realize the effective differentiation between the focal area and the adjacent area. It provides a new method for identifying the animal model of excitatory pain point, and has important research and application value for clinical diagnosis and curative effect evaluation of myofascial excitatory pain point related diseases.
【作者单位】：中国医学科学院北京协和医学院生物医学工程研究所激光医学实验室;解放军总医院超声科;
【分类号】：R-332;R686.3

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