正中神经电刺激与常规疗法治疗昏迷患者促醒疗效的meta分析
发布时间：2018-08-31 14:02
【摘要】：目的:系统评价正中神经电刺激与常规促醒疗法在治疗昏迷患者疗效上的不同效果。方法:计算机检索CNKI、Wan Fang Data、VIP、中国生物医学文献数据库和Pub Med及Web of Science,收集了关于正中神经电刺激治疗与常规昏迷促醒治疗的随机对照试验(RCT),检索时间均从建库至2016年5月。由2名研究者按照纳入与排除标准筛选文献,提取数据和评价纳入研究的方法学质量后,采用Rev Man 5.1.0软件进行meta分析。结果:纳入12个研究,1001例患者,观察组503例,对照组498例。正中神经电刺激能提高GCS评分:2—4周(Z=3.24,P0.01),8周(Z=3.44,P0.01);有改善脑干诱发电位(Z=2.66,P0.01),脑电图(Z=3.05,P0.01)和患者言语功能(Z=4.30,P0.01)的效果,差异有显著性意义。结论:正中神经电刺激疗法可以提高患者GCS评分,改善脑血流量,对促进患者清醒有较好效果,由于受纳入研究质量和样本量的影响,今后仍需开展大样本,高质量的RCT进行验证。
[Abstract]:Objective: to evaluate the efficacy of median nerve stimulation and conventional wake-up therapy in the treatment of coma patients. Methods: CNKI,Wan Fang Data,VIP, Chinese biomedical literature database, Pub Med and Web of Science, were searched by computer. The retrieval time of (RCT), in the randomized controlled trials of median nerve electrical stimulation therapy and conventional coma wake-up therapy was from the establishment of the database to May 2016. According to the inclusion and exclusion criteria, two researchers sifted the literature, extracted the data and evaluated the methodological quality of the study. The meta analysis was carried out with Rev Man 5.1.0 software. Results: one hundred and one patients were enrolled in 12 studies, 503 cases in the observation group and 498 cases in the control group. Median nerve stimulation could improve the GCS score from 2 to 4 weeks (Z = 3.24 卤P0.01) to 8 weeks (Z = 3.44 vs P0.01), improve the brainstem evoked potential (ZG), electroencephalogram (EEG) and speech function of the patients (ZH 4.30P0.01). Conclusion: median nerve electrical stimulation therapy can improve the GCS score, improve cerebral blood flow and promote the patients' wakefulness. Due to the influence of the quality and sample size of the included study, it is necessary to carry out large samples in the future. High quality RCT is verified.
【作者单位】： 南昌大学第一附属医院康复医学科;
【基金】：国家自然科学基金资助项目(81260295) 江西省自然科学基金资助项目(20132BAB205063) 江西省卫生厅科技计划项目(20131026)
【分类号】：R651.15
，
本文编号：2215216
[Abstract]:Objective: to evaluate the efficacy of median nerve stimulation and conventional wake-up therapy in the treatment of coma patients. Methods: CNKI,Wan Fang Data,VIP, Chinese biomedical literature database, Pub Med and Web of Science, were searched by computer. The retrieval time of (RCT), in the randomized controlled trials of median nerve electrical stimulation therapy and conventional coma wake-up therapy was from the establishment of the database to May 2016. According to the inclusion and exclusion criteria, two researchers sifted the literature, extracted the data and evaluated the methodological quality of the study. The meta analysis was carried out with Rev Man 5.1.0 software. Results: one hundred and one patients were enrolled in 12 studies, 503 cases in the observation group and 498 cases in the control group. Median nerve stimulation could improve the GCS score from 2 to 4 weeks (Z = 3.24 卤P0.01) to 8 weeks (Z = 3.44 vs P0.01), improve the brainstem evoked potential (ZG), electroencephalogram (EEG) and speech function of the patients (ZH 4.30P0.01). Conclusion: median nerve electrical stimulation therapy can improve the GCS score, improve cerebral blood flow and promote the patients' wakefulness. Due to the influence of the quality and sample size of the included study, it is necessary to carry out large samples in the future. High quality RCT is verified.
【作者单位】： 南昌大学第一附属医院康复医学科;
【基金】：国家自然科学基金资助项目(81260295) 江西省自然科学基金资助项目(20132BAB205063) 江西省卫生厅科技计划项目(20131026)
【分类号】：R651.15
，
本文编号：2215216
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