血清白细胞介素-18、-10与肿瘤坏死因子-α在老年脓毒血症患者预后中的预测价值
发布时间：2018-09-17 19:46
【摘要】：目的探讨血清白细胞介素(IL)-18、IL-10与肿瘤坏死因子(TNF)-α对老年脓毒血症患者预后的预测价值。方法选取该院2012年1月至2015年1月老年脓毒血症患者89例,根据预后状况将患者分为存活组(48例)与病死组(41例),采用酶联免疫吸附法(ELISA)测定血清IL-18、IL-10、TNF-α水平。采用Pearson相关系数分析血清指标与急性生理学与慢性健康状况评估系统Ⅱ(APACHEⅡ)评分、序贯器官衰竭估计(SOFA)评分的关系,采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析血清指标对老年脓毒血症患者预后的预测价值。结果存活组血清IL-18、IL-10与TNF-α水平明显低于病死组,APACHEⅡ评分、SOFA评分明显低于病死组(P0.05)。经Pearson相关系数分析显示,IL-18、IL-10、TNF-α与APACHEⅡ评分、SOFA评分呈明显正相关(P0.05)。ROC分析显示,IL-18、IL-10、TNF-α的AUC分别为0.723、0.916、0.851(P0.05)。结论血清IL-18、IL-10与TNF-α对老年脓毒血症患者预后具有重要的预测价值,其中血清IL-10预测价值最佳。
[Abstract]:Objective to investigate the prognostic value of serum interleukin (IL)-18 sil-10 and tumor necrosis factor (TNF)-伪 in elderly patients with sepsis. Methods Eighty-nine elderly patients with sepsis from January 2012 to January 2015 were divided into survival group (48 cases) and dead group (41 cases) according to their prognosis. Serum IL-18,IL-10,TNF- 伪 levels were measured by Elisa (ELISA). Pearson correlation coefficient was used to analyze the relationship between serum index and acute physiology and chronic health assessment system 鈪，
本文编号：2246904
[Abstract]:Objective to investigate the prognostic value of serum interleukin (IL)-18 sil-10 and tumor necrosis factor (TNF)-伪 in elderly patients with sepsis. Methods Eighty-nine elderly patients with sepsis from January 2012 to January 2015 were divided into survival group (48 cases) and dead group (41 cases) according to their prognosis. Serum IL-18,IL-10,TNF- 伪 levels were measured by Elisa (ELISA). Pearson correlation coefficient was used to analyze the relationship between serum index and acute physiology and chronic health assessment system 鈪，
本文编号：2246904
本文链接：https://www.wllwen.com/yixuelunwen/jjyx/2246904.html
最近更新
教材专著
