急性脑梗死患者血清陷窝蛋白1水平与早期神经功能恶化的关系

发布时间：2018-09-18 18:05

【摘要】：目的·研究急性脑梗死患者血清陷窝蛋白1(Cav-1)水平与早期神经功能恶化(END)的关系。方法·选取2016年7月—2017年1月重庆医科大学附属第一医院神经内科收治的急性脑梗死患者126例,ELISA法检测血清Cav-1水平,同时采用美国国立卫生研究院脑卒中量表(NIHSS)、格拉斯哥昏迷量表(GCS)评估患者神经功能缺损程度。与入院NIHSS基线评分比较,若患者入院3 d内第2次NIHSS运动评分项增加≥1分或总分增加≥2分,则归入END组,否则归入非END组。多因素Logistic回归分析患者发生END的独立预测因子,ROC曲线分析Cav-1预测END的准确性。结果·END组血清Cav-1水平较非END组显著升高[(29.88±19.57)ng/m L vs(16.08±13.37)ng/m L,P=0.000]。ROC曲线分析血清Cav-1预测END的最佳切点为16.55 ng/m L,灵敏度和特异度分别为73.33%和74.07%。Logistic分析显示,Cav-1≥16.55 ng/m L是急性脑梗死患者发生END的独立预测因子(OR=4.936,95%CI为1.608~15.155,P=0.005)。结论·血清Cav-1水平是急性脑梗死发生END的独立预测因子。
[Abstract]:Objective to study the relationship between serum Cav-1 level and (END) in patients with acute cerebral infarction. Methods from July 2016 to January 2017, 126 patients with acute cerebral infarction treated in Department of Neurology, the first affiliated Hospital of Chongqing Medical University, were selected to detect serum Cav-1 level by Elisa. At the same time, (NIHSS), Glasgow coma scale (GCS) was used to assess the degree of neurological impairment. Compared with the baseline score of NIHSS in admission, if the NIHSS motor score of the second time within 3 days of admission was increased 鈮，

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