舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者的临床观察

发布时间：2018-09-19 16:34

【摘要】：目的:观察舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者的临床疗效及安全性。方法:将96例创伤性蛛网膜下腔出血患者按随机数字表法分为对照组和观察组,各48例。对照组患者给予氨甲环酸注射液、尼莫地平注射液和胞磷胆碱注射液进行常规治疗,每日行腰椎穿刺,测颅内压引流脑脊液;观察组患者在对照组基础上加用舒血宁注射液20 ml加入5%葡萄糖注射液250 ml中,ivgtt,qd。两组患者均连续治疗2周。观察两组患者的临床疗效及治疗前后格拉斯哥指数(GCS)评分、动脉血流速度(MCA)水平,并记录不良反应发生率。结果:观察组患者良好率(60.42%)显著高于对照组患者(31.25%),差异有统计学意义(P0.05);治疗前及治疗后3、5 d,两组患者GCS评分、MCA比较,差异无统计学意义(P0.05);治疗后7、14 d,两组患者GCS评分明显升高,MCA水平明显降低,且观察组明显优于对照组,差异有统计学意义(P0.05);观察组患者脑血管痉挛、脑梗死和脑出血发生率分别为8.33%、4.17%和4.17%,对照组患者分别为16.67%、12.50%和16.67%,观察组明显低于对照组,差异有统计学意义(P0.05)。结论:舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者疗效显著,且不良反应发生率较低。
[Abstract]:Objective: to observe the efficacy and safety of Shuxuening injection in the treatment of traumatic subarachnoid hemorrhage. Methods: 96 patients with traumatic subarachnoid hemorrhage were randomly divided into control group (n = 48) and observation group (n = 48). Patients in the control group were given routine treatment with carbamoic acid injection, nimodipine injection and citicoline injection, lumbar puncture was performed daily, and intracranial pressure was measured to drain cerebrospinal fluid. The patients in the observation group were treated with Shuxuening injection for 20 ml and 5% glucose injection for 250 ml on the basis of the control group. The patients in both groups were treated continuously for 2 weeks. The clinical efficacy, Glasgow index (GCS) score, arterial blood flow velocity (MCA) and the incidence of adverse reactions were observed before and after treatment. Results: the good rate of patients in the observation group (60.42%) was significantly higher than that in the control group (31.25%), and the difference was statistically significant (P0.05). There was no significant difference between the two groups (P0.05); at 7d after treatment, the GCS score of the two groups significantly increased and decreased, and the observation group was significantly better than the control group, the difference was statistically significant (P0.05); the observation group patients with cerebral vasospasm, The incidence of cerebral infarction and intracerebral hemorrhage were 8.33% and 4.17%, respectively, and those in the control group were 16.67% and 16.67%, respectively, which were significantly lower in the observation group than in the control group (P0.05). Conclusion: Shuxuening injection is effective in the treatment of traumatic subarachnoid hemorrhage.
【作者单位】：三峡大学仁和医院神经外科;
【分类号】：R651.15

【相似文献】