急性心肌梗死后心力衰竭患者米力农微量泵入治疗的临床观察

发布时间：2018-10-13 19:05

【摘要】：目的探讨米力农微量泵入治疗急性心肌梗死后心力衰竭患者的效果及其对血流动力学的影响。方法选取62例急性心肌梗死后心力衰竭患者,随机分成观察组和对照组。在给予常规治疗的基础上,对照组采取西地兰治疗,西地兰注射液0.025 mg/(kg·d)加入到0.9%氯化钠注射液20 m L中静注,1次/d,7 d为1个疗程。观察组采用米力农治疗,0.375~0.75 mg/(kg·d)加入到0.9%的氯化钠溶液50 m L中,微量泵泵入,1次/d,7 d为1个疗程,对比两组7 d后的治疗疗效、血流动力学指标、B型尿钠肽及不良反应。结果观察组总有效率显著高于对照组(P0.01),治疗后的左室舒张末内径、左室射血分数、心脏指数、体循环血管阻力等血流动力学指标优于对照组(P均0.01),不良反应总发生率高于对照组(P0.01)。各组B型尿钠肽、舒张压、收缩压、心率较治疗前有显著改善,以观察组为著(P均0.05或0.01)。结论米力农微量泵入能明显改善急性心肌梗死后心力衰竭患者的临床疗效及血流动力学,但不良反应稍高。
[Abstract]:Objective to investigate the effect of milrinone micropump in the treatment of heart failure after acute myocardial infarction and its effect on hemodynamics. Methods Sixty-two patients with heart failure after acute myocardial infarction were randomly divided into observation group and control group. On the basis of routine treatment, the control group was treated with cilidian. The injection of cilidian 0.025 mg/ (kg d) was injected intravenously into 0.9% sodium chloride injection 20 mL, once a day for 7 days as a course of treatment. The observation group was treated with milrinone, 0.375 and 0.75 mg/ (kg d) added to 0.9% sodium chloride solution 50 mL, the micropump was pumped in, once a day for 7 days as a course of treatment. The therapeutic effect, hemodynamic index, type B urinary natriuretic peptide and adverse reactions were compared between the two groups after 7 days. Results the total effective rate of the observation group was significantly higher than that of the control group (P0.01). The left ventricular end-diastolic diameter, left ventricular ejection fraction, cardiac index after treatment were significantly higher in the observation group than in the control group (P0.01). The hemodynamic indexes such as systemic vascular resistance were better than those of the control group (P0.01), and the total incidence of adverse reactions was higher than that of the control group (P0.01). Type B natriuretic peptide, diastolic blood pressure, systolic blood pressure and heart rate were significantly improved in the observation group (P 0.05 or 0.01). Conclusion milrinone micropump can significantly improve the clinical efficacy and hemodynamics of patients with heart failure after acute myocardial infarction, but the adverse reaction is slightly higher.
【作者单位】：青岛市黄岛区人民医院;鲁南制药集团股份有限公司;
【分类号】：R542.22;R541.6

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