血清可溶性髓样细胞触发受体-1对重症脓毒症患者预后判断价值

发布时间：2018-10-31 12:05

【摘要】：目的研究血清可溶性髓样细胞触发受体-1(s TREM-1)浓度检测对重症脓毒症患者预后的判断价值。方法回顾性分析重症脓毒症患者共83例,根据28 d死亡结局分为存活组(n=63)和死亡组(n=20),比较2组患者在基本情况、入院24 h APACHEⅡ评分最高值、全血C反应蛋白(C-reactive protein,CRP)和乳酸(lactate,Lac)浓度、血清降钙素(procalcitonin,PCT)和s TREM-1浓度等方面的差异,并绘制ROC曲线分析相关指标对疾病的预后判断及诊断价值,多因素Logistic回归分析探讨与疾病死亡相关的危险因素。结果 2组患者基本情况差异无统计学意义(P0.05)。死亡组患者在APACHEⅡ评分最高值和血清s TREM-1浓度上要高于存活组(P0.05),而在血清PCT、全血CRP和Lac浓度上2组间比较,则差异无统计学意义(P0.05)。ROC曲线分析结果表明,血清s TREM-1浓度对重症脓毒症患者死亡预测的曲线下面积为0.77。多因素Logistic回归分析结果显示,APACHEⅡ评分和血清s TREM-1浓度是重症脓毒症患者死亡的独立高危因素。结论血清s TREM-1浓度有望成为预测重症脓毒症患者预后的可靠指标,也可能是重症脓毒症患者死亡的独立危险因素。
[Abstract]:Objective to study the prognostic value of serum soluble myeloid cell trigger receptor-1 (s TREM-1) in patients with severe sepsis. Methods Eighty-three patients with severe sepsis were retrospectively analyzed. According to the death outcome of 28 days, the patients were divided into two groups: survival group (n = 63) and death group (n = 20). The two groups were compared in the basic condition and the highest APACHE 鈪，

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