新疆维汉急性心肌梗死患者N末端脑钠肽原水平对比研究
发布时间：2018-11-08 06:52
【摘要】：目的：观察维吾尔族和汉族急性心肌梗死患者经皮冠状动脉介入治疗后血浆N末端脑钠肽前体（NT-proBNP）动态变化趋势特点，分析该评价指标与左室功能（LVEF）、同型半胱氨酸（HCY）的关系，进一步探讨NT-proBNP在维、汉两组之间是否有民族差异及NT-proBNP的预后评估意义，最终尝试选定维吾尔族和汉族作为预后评估指标时的检测时间截点。方法：纳入2011年3月至2012年2月之间我院心脏中心行急诊PCI治疗的AMI患者128例，根据族别分为汉族组（n=78）和维吾尔族组(n=50)，记录罪犯血管情况，分别完善同型半胱氨酸检测，术前、术后14~48h、术后49~72h的连续NT-proBNP快速床旁检测，，术后6个月随访心脏LVEF值。所有数据均采用SPSS17.0统计软件进行统计分析。结果：维汉两民族的NT-proBNP变化趋势存在各自的特点，维吾尔族的平均NT-proBNP水平较汉族患者低（P0.05）；PCI前后不同时间段NT-proBNP的差异有显著统计学意义（F=56.316，P0.05）。维汉两民族不同罪犯血管NT-proBNP水平亦有差异；汉族组6个月时LVEF值与术后14~48h段的NT-proBNP值相关性最好，呈负相关(r=-0.7），而维族组LVEF与三个时间段的NT-proBNP值相关性基本一致，呈负相关（r=-0.8）。结论：NT-proBNP的分泌水平具有一定的民族差异，汉族PCI患者的预后评估的最佳时间截点建议为14~48h，维族患者49~72h的NT-proBNP值可较准确的评估。
[Abstract]:Objective: to observe the trend of plasma N-terminal brain natriuretic peptide precursor (NT-proBNP) in patients with acute myocardial infarction (AMI) in Uygur and Han nationality after percutaneous coronary intervention (PCI). The relationship between homocysteine (HCY) (Hcy (HCY) and the prognostic significance of NT-proBNP in Uygur and Han groups, and the prognostic value of NT-proBNP. Finally, we try to select Uygur and Han as prognostic indicators. Methods: from March 2011 to February 2012, 128 patients with AMI received emergency PCI treatment in our heart center were divided into two groups: Han nationality group (n = 78) and Uygur group (n = 50). The blood vessels of the criminals were recorded. Homocysteine was detected by continuous NT-proBNP fast bedside test before operation, at 1448 hours after operation and 4972 hours after operation. The cardiac LVEF values were followed up 6 months after operation. All the data were analyzed by SPSS17.0 software. Results: the variation trend of NT-proBNP in Uygur and Han nationalities had their own characteristics. The average NT-proBNP level of Uygur was lower than that of Han (P0.05). The difference of NT-proBNP before and after PCI was statistically significant (P 0.05). The levels of vascular NT-proBNP of different criminals in Uygur and Han nationalities were also different. The correlation between LVEF and NT-proBNP at 144h postoperatively was the best in Han group at 6 months (r = -0.7), but the correlation between LVEF and NT-proBNP in Uygur group was almost the same (r ~ (-0.8). Conclusion: the secretory level of NT-proBNP is different in different nationalities. The best time for prognosis evaluation of PCI patients in Han nationality is 144h. The NT-proBNP value of 4972h in Uygur nationality patients can be accurately evaluated.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R542.22
本文编号：2317705
[Abstract]:Objective: to observe the trend of plasma N-terminal brain natriuretic peptide precursor (NT-proBNP) in patients with acute myocardial infarction (AMI) in Uygur and Han nationality after percutaneous coronary intervention (PCI). The relationship between homocysteine (HCY) (Hcy (HCY) and the prognostic significance of NT-proBNP in Uygur and Han groups, and the prognostic value of NT-proBNP. Finally, we try to select Uygur and Han as prognostic indicators. Methods: from March 2011 to February 2012, 128 patients with AMI received emergency PCI treatment in our heart center were divided into two groups: Han nationality group (n = 78) and Uygur group (n = 50). The blood vessels of the criminals were recorded. Homocysteine was detected by continuous NT-proBNP fast bedside test before operation, at 1448 hours after operation and 4972 hours after operation. The cardiac LVEF values were followed up 6 months after operation. All the data were analyzed by SPSS17.0 software. Results: the variation trend of NT-proBNP in Uygur and Han nationalities had their own characteristics. The average NT-proBNP level of Uygur was lower than that of Han (P0.05). The difference of NT-proBNP before and after PCI was statistically significant (P 0.05). The levels of vascular NT-proBNP of different criminals in Uygur and Han nationalities were also different. The correlation between LVEF and NT-proBNP at 144h postoperatively was the best in Han group at 6 months (r = -0.7), but the correlation between LVEF and NT-proBNP in Uygur group was almost the same (r ~ (-0.8). Conclusion: the secretory level of NT-proBNP is different in different nationalities. The best time for prognosis evaluation of PCI patients in Han nationality is 144h. The NT-proBNP value of 4972h in Uygur nationality patients can be accurately evaluated.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R542.22
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