丁苯酞治疗急性缺血性脑卒中临床疗效的系统评价

发布时间：2018-11-12 21:14

【摘要】：目的探讨急性缺血性脑卒中患者应用丁苯酞的临床疗效。方法通过检索自2004年1月~2014年1月期间英国医学会电子全文期刊数据库、荷兰医学文摘数据库、学术期刊集成全文数据库、考克兰图书馆、西文生物医学期刊文献数据库、美国国立医学图书馆生物医学信息检索系统、万方数据库、维普中文科技期刊全文数据库、中文科技期刊数据库、中国生物医学文献数据库、中国学术期刊全文数据库等数据库内相关的随机对照试验(RCT),对纳入文献的质量进行严格评价和资料提取,使用Stata/SE version 12.0软件对纳入研究进行系统评价。结果最终纳入7篇RCT,共796例患者,其中396例予以丁苯酞、400例予以常规治疗。系统评价结果显示,与常规治疗组相比,丁苯酞治疗11 d及21 d亚组NIHSS显著降低(I~2=25.9%,OR=-0.35,95%CI:-0.52~-0.19,P=0.264;I~2=42.9%,OR=-0.42,95%CI:-0.57~-0.26,P=0.199),Barthel指数显著升高(I~2=36.9%,OR=0.45,95%CI:0.21~0.68,P=0.218;I~2=42.7%,OR=0.44,95%CI:0.23~0.64,P=0.111)。结论应用丁苯酞治疗急性缺血性脑卒中,能显著缓解患者起病后11 d及21 d的神经功能的缺损程度,并显著改善其身体机能,疗效确切,值得临床推广。
[Abstract]:Objective to investigate the clinical effect of butyphthalide in patients with acute ischemic stroke. Methods from January 2004 to January 2014, the database of electronic full-text journals of the British Medical Association, the Netherlands Medical Abstract Database, the academic Journal Integration Full-text Database, the Cockland Library and the Western Biomedical Journal Literature Database were searched. Us National Medical Library Biomedical Information Retrieval system, Wanfang Database, Weipu full text Database of Chinese Sci-tech Journals, Chinese Sci-tech Journals Database, Chinese Biomedical Literature Database, The relevant randomized controlled trials (RCT),) in the full text database of Chinese academic journals were used to evaluate the quality of the literature and extract the data. The software Stata/SE version 12.0 was used to evaluate the inclusion research systematically. Results A total of 796 patients with RCT, were included, of whom 396 were treated with butyphthalide and 400 were treated with routine therapy. The results of systematic evaluation showed that compared with the routine treatment group, the NIHSS of 11 d and 21 d subgroups of butyphthalide treatment was significantly lower than that of the routine treatment group (I _ (22) ~ (25. 9) ~ (-0.35) ~ 95 ~ (95) CI: -0.52 ~ (-0.19) ~ (-1) ~ (-0.19) P ~ (+) 0.264; (II) 42.9% OR-0.42 + 95% CI-0.57 ~ -0.26) the), Barthel index is significantly higher (I / O ~ (36.9) = 0.45 ~ 95 CI: 0.21 ~ 0.68 / P = 0.218; I = 0. 45% ~ 0. 21% ~ 0. 68% P = 0. 218). I have an order of 0.44 to 95 CI: 0.23 and 0.64 P0.111). Conclusion the treatment of acute ischemic stroke with butyphthalide can significantly relieve the neurological deficit and improve the body function of patients 11 and 21 days after the onset of the disease. The curative effect is accurate and worthy of clinical promotion.
【作者单位】：湖北省鄂州市中心医院神经内科;
【分类号】：R743.3

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