牛磺酸片治疗急性呼吸窘迫综合征的临床研究

发布时间：2018-11-15 06:39

【摘要】：目的观察牛磺酸片治疗急性呼吸窘迫综合征(ARDS)的临床疗效及安全性。方法将100例ARDS患者随机分为对照组50例和试验组50例。2组患者均予以纠正缺氧、机械通气、液体管理等对症治疗;同时试验组予以口服牛磺酸片60 mg·kg~(-1)·d~(-1),对照组予以口服同等剂量的安慰剂。2组患者均治疗7 d。比较2组患者的临床疗效、呼吸窘迫临床症状、氧合指数(PaO_2/FiO_2)、血管性血友病因子(vWF)、可溶性细胞间黏附因子-1(s ICAM-1),以及药物不良反应发生率。结果治疗后,试验组和对照组的有效率分别为66.00%(33例/50例)和24.00%(12例/50例),差异有统计学意义(P0.05)。治疗7 d后,试验组和对照组PaO_2/FiO_2分别为(289.51±67.63)和(213.49±63.67)mm Hg,vWF分别为(167.71±40.38)mg·L~(-1)和(194.79±46.57)mg·L~(-1),s ICAM-1分别为(387.93±200.46)和(499.11±218.12)mm Hg,差异均有统计学意义(均P0.05)。2组均未发现药物不良反应。结论牛磺酸片治疗急性呼吸窘迫综合征的临床疗效显著,可有效改善患者缺氧状态,提高氧合指数,降低相关炎性因子。
[Abstract]:Objective to observe the efficacy and safety of taurine tablets in the treatment of acute respiratory distress syndrome (ARDS). Methods 100 patients with ARDS were randomly divided into control group (n = 50) and experimental group (n = 50). At the same time, the experimental group was given orally taurine tablets for 60 mg kg~ (-1) D1, while the control group was given the same dose of placebo. The patients in both groups were treated for 7 days. The clinical efficacy, clinical symptoms of respiratory distress, oxygenation index (PaO_2/FiO_2) and soluble intercellular adhesion factor-1 (s ICAM-1) of von Willebrand factor (vWF), were compared between the two groups. And the incidence of adverse drug reactions. Results after treatment, the effective rates of the experimental group and the control group were 66.00% (33 / 50) and 24.00% (12 / 50), respectively. The difference was statistically significant (P0.05). After 7 days of treatment, the PaO_2/FiO_2 of the experimental group and the control group were (289.51 卤67.63) and (213.49 卤63.67) mm Hg,vWF, respectively (167.71 卤40.38) mg L ~ (-1) and (194.79 卤46.57) mg L ~ (-1). S ICAM-1 was (387.93 卤200.46) and (499.11 卤218.12) mm Hg, respectively. Conclusion taurine tablet is effective in the treatment of acute respiratory distress syndrome. It can effectively improve the anoxic state, increase oxygenation index and decrease the related inflammatory factors in patients with acute respiratory distress syndrome.
【作者单位】：淮安市第一人民医院呼吸科;
【基金】：江苏省卫生计生委面上科研基金资助项目(H201554)
【分类号】：R563.8

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