氧化低密度脂蛋白、血栓前体蛋白在急性脑梗死中的表达及临床意义探讨

发布时间：2018-11-17 19:04

【摘要】：目的：动态观察氧化低密度脂蛋白(Ox-LDL)、血栓前体蛋白(TpP)在急性脑梗死中的表达,并探讨其临床意义。方法：采用酶联免疫吸附测定(ELISA)法测定44例脑梗死患者急性期、恢复期组及30例健康对照者血清Ox-LDL和血浆TpP水平,并对脑梗死患者行美国国立卫生研究院卒中量表(NIHSS)评分,分析Ox-LDL、TpP在急性脑梗死中的表达及与NIHSS评分的关系。结果：脑梗死患者血清Ox-LDL和血浆TpP均较对照组升高,急性期组Ox-LDL及TpP显著高于恢复期组及对照组,差异具有统计学意义(P0.01)；脑梗死组血浆TpP浓度与NIHSS评分呈正相关(P0.01),Ox-LDL浓度高低与NIHSS评分无关(P0.05)；脑梗死组Ox-LDL与TpP水平呈正相关(r=0.521,P0.05)。结论：急性脑梗死患者血清Ox-LDL、血浆TpP表达上调,且其水平随临床病程不同而发生变化,它们可能共同参与了急性脑梗死的发生、发展过程；血浆TpP可能与脑梗死严重程度相关,或可作为急性脑梗死病情及预后判断的指标。
[Abstract]:Aim: to investigate the expression of oxidized low density lipoprotein (Ox-LDL) and thromboprecursor protein (TpP) in acute cerebral infarction and its clinical significance. Methods: the levels of serum Ox-LDL and plasma TpP in 44 patients with acute cerebral infarction, in convalescent group and 30 healthy controls were measured by (ELISA) assay. The (NIHSS) score of stroke scale of the National Institutes of Health (NIH) was used to analyze the expression of Ox-LDL,TpP in acute cerebral infarction and the relationship between Ox-LDL,TpP and NIHSS score. Results: the serum Ox-LDL and plasma TpP in patients with cerebral infarction were higher than those in the control group. The Ox-LDL and TpP in the acute phase group were significantly higher than those in the convalescent group and the control group (P0.01). There was a positive correlation between plasma TpP concentration and NIHSS score in cerebral infarction group (P0.01), but no correlation between Ox-LDL concentration and NIHSS score (P0.05), and there was a positive correlation between Ox-LDL and TpP level in cerebral infarction group (r = 0.521 P 0.05). Conclusion: the expression of serum Ox-LDL, TpP is up-regulated in patients with acute cerebral infarction, and its level changes with the clinical course. They may be involved in the occurrence and development of acute cerebral infarction. Plasma TpP may be related to the severity of cerebral infarction, or may be used as an indicator of the severity and prognosis of acute cerebral infarction.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R743.3

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