红外热疗预防深二度烧伤创面铜绿假单胞菌感染的疗效

发布时间：2018-11-24 11:50

【摘要】：目的观察红外热疗对于预防深二度烧伤创面铜绿假单胞菌感染的临床疗效。方法选取2015年1月至2016年10月笔者单位烧伤科收治的43例以深二度创面为主的烧伤住院患者,随机将患者分配至磺胺嘧啶银联合创面红外热疗组(简称试验组)及磺胺嘧啶银组(简称对照组)。在治疗前和治疗后第3、7、14、21、28天,行创面分泌物评分、铜绿假单胞菌培养、创面愈合率、创面愈合时间及创面总体评价等指标,同时观察不良反应,最后对数据进行统计分析。结果 (1)两组患者在年龄、性别、烧伤总面积等方面比较,差异均无统计学意义(均P0.05)。(2)治疗第3、7、14天试验创面分泌物评分分别为(2.3±0.6、1.7±0.5、1.0±0.6),明显低于常规治疗组(2.8±0.4、2.1±0.7、1.7±0.7)(均P0.05);治疗前及治疗第21、28天,两组患者创面分泌物评分相近。(3)两组绿脓杆菌检出率在治疗第7、14、21天试验组铜绿假单胞菌阳性率分别为(8/22、6/22、0/22),明显低于对照组(18/21、15/21、4/21)(均P0.05)。(4)治疗后第7、14、21天,试验组创面愈合率分别为[(39.2±11.1)%、(71.3±22.0)%、(94.6±7.3)%],高于对照组[(22.9±13.1)%、(54.8±19.9)%、(87.6±9.8)%],各组间比较差异有统计学意义(均P0.05);试验组患者创面愈合时间[(21.1±6.5)d]明显短于对照组[(26.2±6.5)d,P0.05]。(5)治疗后第14和21天试验组治疗总体评价优于对照组(均P0.05)。结论创面红外热疗通过减少深二度烧伤创面分泌物,从而有效控制铜绿假单胞菌定植感染,进而有助于创面愈合,达到一定缩短愈合时间的作用。
[Abstract]:Objective to observe the clinical effect of infrared hyperthermia on prevention of Pseudomonas aeruginosa infection in deep second degree burn wounds. Methods from January 2015 to October 2016, 43 patients with deep second degree burn were selected. Patients were randomly assigned to silver sulfadiazine combined with infrared hyperthermia group (test group) and silver sulfadiazine group (control group). The score of wound secretion, the culture of Pseudomonas aeruginosa, the rate of wound healing, the time of wound healing and the overall evaluation of wound were observed before and 28 days after treatment. At the same time, the adverse reactions were observed and analyzed statistically. Results (1) there was no significant difference in age, sex and total burn area between the two groups (P0.05). On the 14th day, the score of wound secretion was (2.3 卤0.6) 卤0.5 卤1.0 卤0.6, which was significantly lower than that in the routine treatment group (2.8 卤0.4 卤2.1 卤0.71.7 卤0.7) (P0.05). Before treatment and on the 21st day of treatment, the scores of wound secretion in the two groups were similar. (3) the positive rate of Pseudomonas aeruginosa in the test group was 8 / 22 / 226 / 22 / 22 on day 7, 14 and 21, respectively. Compared with the control group (18 / 21, 15 / 21, 4 / 21) (P0.05). (4), the wound healing rate in the experimental group was (39.2 卤11.1)%, (71.3 卤22.0)%, (94.6 卤7.3)%, respectively. It was higher than the control group [(22.9 卤13.1)%, (54.8 卤19.9)%, (87.6 卤9.8)%]. The wound healing time in the test group [(21.1 卤6.5) days] was significantly shorter than that in the control group [(26.2 卤6.5) days]. (5) the overall evaluation of treatment in the experimental group was better than that in the control group on the 14th and 21st days after treatment (P0.05). Conclusion Infrared hyperthermia can effectively control the infection of Pseudomonas aeruginosa by reducing the secretion of deep second degree burn wound, which can help the wound healing and shorten the healing time.
【作者单位】：第二军医大学第一附属医院长海医院烧伤外科;
【基金】：国家自然科学基金国际(地区)合作与交流项目(编号:81120108015) 国家973计划项目(编号:2012CB518100) 十二五科技计划项目(编号:AWS11J008)
【分类号】：R644

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