急性心肌梗死PCI治疗后血清基质金属蛋白酶9、C反应蛋白、P选择素的变化及意义

发布时间：2018-12-10 15:33

【摘要】：目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)治疗后血清基质金属蛋白酶9(MMP-9)、C反应蛋白(CRP)、P选择素水平的变化及临床意义。方法选择PCI治疗AMI患者50例(观察组)和同期体检健康者50例(对照组),采用酶联免疫吸附法检测对照组及观察组治疗前、治疗第5天血清MMP-9、CRP、P选择素水平。结果对照组血清MMP-9、CRP、P选择素分别为(312.67±82.78)、(4.14±0.32)、(121.27±69.12)mg/L。观察组术前血清MMP-9、CRP、P选择素分别为(704.03±122.53)、(13.22±2.11)、(193.34±103.52)mg/L,治疗第5天分别为(337.14±89.25)、(4.26±1.35)、(125.11±71.24)mg/L。观察组术前血清MMP-9、CRP、P选择素水平均高于对照组(P均0.05),且术后较术前降低(P均0.05),术后与对照组比较无统计学差异(P均0.05)。结论 PCI术后AMI患者血清MMP-9、CRP以及P选择素水平均降低,检测三者血清水平可用来评定AMI的治疗效果及临床预后。
[Abstract]:Objective to investigate the changes and clinical significance of serum matrix metalloproteinase-9 (MMP-9), C reactive protein (CRP), P selectin) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods 50 AMI patients (observation group) and 50 healthy persons (control group) were treated with PCI. The serum MMP-9,CRP,P selectin levels were detected by Elisa in the control group and the observation group on the 5th day before treatment. Results the serum MMP-9,CRP,P selectin in the control group was (312.67 卤82.78), (, 4.14 卤0.32), (, 121.27 卤69.12) mg/L., respectively. The serum MMP-9,CRP,P selectin levels were (704.03 卤122.53), () 13.22 卤2.11), (193.34 卤103.52) mg/L, on the 5th day (337.14 卤89.25), (, 4.26 卤1.35), respectively. (125.11 卤71.24) mg/L. The levels of serum MMP-9,CRP,P selectin in the observation group were higher than those in the control group (all P 0. 05), and decreased after operation (P 0. 05), but there was no significant difference between the two groups after operation (P 0. 05). Conclusion the levels of serum MMP-9,CRP and P-selectin in patients with AMI after PCI were all decreased. The serum levels of MMP-9,CRP and P-selectin could be used to evaluate the therapeutic effect and clinical prognosis of AMI.
【作者单位】：珠海市人民医院;
【分类号】：R542.22

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