听觉统合训练对额叶颅脑损伤患者记忆功能、认知功能及血清脑源性神经营养因子的影响

发布时间：2018-12-21 13:20

【摘要】：目的探讨听觉统合训练对额叶颅脑损伤患者记忆功能、认知功能和血清脑源性神经营养因子(BDNF)的影响。方法采用数字随机法将40例额叶颅脑损伤患者分为对照组(20例)和听觉统合训练组(20例)。对照组给予常规康复治疗;听觉统合训练组给予听觉统合训练,1次/d,5次/w。治疗前后,分别采用修订的韦氏记忆量表(WMS-CR)评测工作记忆,威斯康星评测系统(WCST)评测认知功能,酶联免疫吸附试验检测血清BDNF的浓度。结果与对照组比较,视听感觉统合训练组WMS-CR评测中的理解、背数和积累分测验得分显著增高;WCST评测的完成分类数、正确应答数、概念化水平百分数、非持续性错误数项评分优于对照组,但总应答数、错误应答数、持续性应答数、持续性错误数差异无统计学意义(P0.05);BDNF血清浓度较对照组升高(P0.05)。结论听觉统合训练可改善额叶颅脑损伤患者的记忆功能、认知功能,提高BDNF水平。
[Abstract]:Objective to investigate the effects of auditory integrative training on memory function, cognitive function and serum brain-derived neurotrophic factor (BDNF) in patients with frontal lobe craniocerebral injury. Methods 40 patients with frontal lobe craniocerebral injury were randomly divided into control group (20 cases) and auditory integrated training group (20 cases). The control group received routine rehabilitation and the auditory integrative training group received auditory integrative training once a day for 5 times per week. Before and after treatment, working memory was evaluated by revised Wechsler memory scale (WMS-CR), cognitive function was assessed by Wisconsin (WCST), and serum BDNF concentration was measured by Elisa. Results compared with the control group, the scores of comprehension, back count and accumulation subtest in the audiovisual sensory integration training group were significantly higher than those in the control group. The scores of complete classification, correct response, conceptualization level, non-persistent error number, WCST evaluation were better than those of the control group, but the total number of responses, the number of error responses, and the number of persistent responses were better than those of the control group. There was no significant difference in the number of persistent errors (P0.05). The serum concentration of BDNF was higher than that of control group (P0.05). Conclusion auditory integrative training can improve the memory function, cognitive function and BDNF level of patients with frontal lobe craniocerebral injury.
【作者单位】：天津市第五中心医院重症医学科;华北理工大学附属医院;
【基金】：河北省科技厅支撑课题(13277776D)
【分类号】：R651.15

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