神经节苷酯钠治疗急性重症颅脑损伤的临床疗效研究

发布时间：2019-01-16 00:56

【摘要】：目的观察神经节苷酯钠治疗急性重症颅脑损伤的临床疗效。方法将90例急性重症颅脑损伤患者随机分为对照组45例和试验组45例。对照组予以静脉滴注5 mL·kg~(-1)20%甘露醇,30 min完毕+0.4 mg·kg~(-1)呋塞米+纳洛酮8 mg+醒脑静注射液20 mL+注射用血凝酶1 kU,连续治疗8周。试验组在对照组的基础上,加用静脉滴注神经节苷脂钠注射液100 mg,连续治疗2周后,改为40 mg·d~(-1)维持治疗6周。比较2组患者的炎性因子、凝血功能及预后情况。结果治疗后,试验组的降钙素基因相关肽明显高于对照组,肿瘤坏死因子、内皮素明显低于对照组(P0.05);试验组的凝血酶时间明显低于对照组,纤维蛋白原明显高于对照组(P0.05),但2组患者的血小板、凝血酶原时间、活化部分凝血酶时间等指标比较差异无统计学意义(P0.05)。试验组的预后良好率为46.67%,明显高于对照组22.22%(P0.05)。结论神经节苷酯钠治疗急性重症颅脑损伤有助于缓解炎性症状,改善凝血功能,提高临床疗效。
[Abstract]:Objective to observe the clinical effect of ganglioside sodium in the treatment of acute severe craniocerebral injury. Methods 90 patients with acute severe craniocerebral injury were randomly divided into control group (n = 45) and experimental group (n = 45). The control group was given 5 mL kg~ (-1) 20% mannitol intravenously. After 30 min, 0.4 mg kg~ (-1) furosemide 8 mg Xingnaojing injection (20 mL) was injected with hemocoagulase 1 kU, for 8 weeks. On the basis of the control group, the experimental group was treated by intravenous injection of ganglioside sodium injection for 2 weeks, then changed to 40 mg D1 for 6 weeks. The inflammatory factors, coagulation function and prognosis of the two groups were compared. Results after treatment, calcitonin gene-related peptide in the experimental group was significantly higher than that in the control group, tumor necrosis factor and endothelin were significantly lower than those in the control group (P0.05). The thrombin time and fibrinogen in the experimental group were significantly lower than those in the control group (P0.05), but the platelet and prothrombin time of the two groups were significantly higher than that of the control group (P0.05). There was no significant difference in activated partial thrombin time (P0.05). The good prognosis rate of the trial group was 46.67, significantly higher than that of the control group 22.22% (P0.05). Conclusion ganglioside sodium can relieve inflammatory symptoms, improve coagulation function and improve clinical efficacy in patients with acute severe craniocerebral injury.
【作者单位】：遵义医学院附属医院神经外科;遵义医学院附属医院护理部;
【基金】：贵州省科学技术基金资助项目(黔科合J字【2013】2330号)
【分类号】：R651.15

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