丁苯酞对急性脑梗死患者血清白介素-6的影响
[Abstract]:Background and objective: thrombolytic therapy for acute cerebral infarction has been widely recognized in clinical practice, but most patients have missed the opportunity of thrombolytic therapy when they come to hospital. Therefore, it is still necessary to explore the intervention from other pathological links in acute cerebral infarction. Current studies have shown that butylphthalide can increase cerebral blood flow and improve microcirculation in ischemic area, protect mitochondrial function, improve energy metabolism after global cerebral ischemia, inhibit calcium influx, and so on, which involve many links of cerebral ischemia pathology. It has certain therapeutic and protective effects on acute cerebral infarction. The purpose of this study was to investigate the effect of buphthalide on the platelet aggregation rate of interleukin-6 (IL-6) and hypersensitive CRP, in patients with acute cerebral infarction (ACI), and to explore the relationship between neurologic deficit and IL-6. Methods: 80 patients with cerebral infarction of internal carotid artery system within 48 hours of onset were randomly divided into treatment group and control group, and 20 healthy persons were taken as normal control group. The treatment group and control group were treated with routine therapy, and the patients with cerebral infarction were divided into two groups: treatment group and control group. Including antiplatelet aggregation, statins and other drugs, the treatment group was treated with bubene peptide capsule 200mg oral on the basis of routine treatment, 3 times / d. The patients with cerebral infarction in the treatment group and control group were assessed with (NIHSS) before treatment and 30 days after treatment. Three months after treatment, the patients with cerebral infarction were treated with modified Rankin score (mRS) to observe the recovery of neurologic function. The platelet aggregation rate of hypersensitive CRP,IL-6, in treatment group and control group was measured before and 7 days after treatment, and the correlation between neural function defect score and hypersensitive CRP,IL-6, platelet aggregation rate was analyzed. Results: 1. The platelet aggregation rate of hypersensitive CRP,IL-6, in the treatment group and the control group was higher than that in the normal control group before treatment (P0.05). After 7 days of treatment, the platelet aggregation rate of hypersensitive CRP,IL-6, in the two groups was significantly higher than that in the control group (P0.05). The platelet aggregation rate of the treatment group was significantly lower than that of the control group, and the platelet aggregation rate of the treatment group was significantly lower than that of the control group (P0.05). The platelet aggregation rate of the treatment group was significantly lower than that of the control group. 2. There was no significant difference between the treatment group and the control group before the treatment; the scores of the two groups after treatment were significantly lower than those before treatment, but the scores of the treatment group after treatment were more significantly lower than that of the control group (P0.05). 3. NIHSS score and mRS score were positively correlated with hypersensitivity CRP,IL-6 and platelet aggregation rate in patients with acute cerebral infarction (P0.05). Conclusion: butylphthalide can significantly improve the symptoms of neurological deficit in patients with acute cerebral infarction and decrease the platelet aggregation rate of hypersensitive CRP,IL-6, in patients with acute cerebral infarction, and the improvement of neural function and hypersensitive CRP,. There was a positive correlation between the level of IL-6 and the decrease of platelet aggregation rate, which suggested that butylphthalide could decrease the level of IL-6, reduce the inflammatory reaction, inhibit platelet aggregation and promote the recovery of nerve function in patients with acute cerebral infarction.
【学位授予单位】:苏州大学
【学位级别】:硕士
【学位授予年份】:2013
【分类号】:R743.3
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