中西医结合方案对脓毒症的早期疗效及血乳酸、胱抑素C水平影响的临床研究

发布时间：2019-03-04 17:57

【摘要】：目的：观察应用中药清瘟败毒饮中西医结合治疗方案治疗脓毒症早期(治疗3天)的临床疗效,以及对血乳酸、胱抑素C水平的影响,探索中药清瘟败毒饮在改善组织缺血缺氧、保护器官功能方面的作用,并探讨清瘟败毒饮治疗脓毒症的机制,为使用清瘟败毒饮治疗脓毒症提供临床证据。方法：选取符合脓毒症诊断标准、中医辨证为气血两燔证的患者53例,将53例患者随机(随机排列表法)分为两组,治疗组26例在西医综合治疗方法基础上加用“清瘟败毒饮”,对照组27例仅给予西医综合方法治疗,疗程3天,观察两组患者的中医症状积分、APACHE II评分、血乳酸、胱抑素C等指标动态变化。结果： 3天后治疗组在改善中医症状积分、APACHE II评分、血乳酸、血胱抑素C水平方面与对照组相当,差异没有统计学意义。结论：应用清瘟败毒饮治疗脓毒症在3天内未能有效提高脓毒症临床疗效,治疗早期在改善组织缺血缺氧、保护肾脏功能方面与对照组相比无差异：
[Abstract]:Objective: to observe the clinical effect of traditional Chinese medicine Qingwen Duduyin on the early stage (3 days of treatment) of sepsis and the effect on the level of blood lactic acid and cystatin C (Cystatin C). To explore the role of Qingwen Gudu Yin in improving tissue ischemia and hypoxia and protecting organ function, and to explore the mechanism of Qingwen Duduyin in the treatment of sepsis, so as to provide clinical evidence for the treatment of sepsis with Qingwen Duduyin. Methods: 53 cases of sepsis were randomly divided into two groups according to the diagnosis criteria of sepsis and syndrome differentiation of qi and blood, and 53 cases were randomly divided into two groups. Twenty-six cases in the treatment group were treated with "Qingwen Di du Yin" on the basis of the comprehensive treatment of western medicine, and 27 cases in the control group were treated only with the western medicine comprehensive method. The course of treatment was 3 days. The, APACHE II score and blood lactic acid of the two groups of patients with symptoms of traditional Chinese medicine were observed. The changes of cystine C and other indexes were dynamic. Results: after 3 days, the scores of, APACHE II, blood lactic acid and cystatin C in the treatment group were similar to those in the control group, and there was no significant difference between the treatment group and the control group. Conclusion: Qingwen Duduyin can not effectively improve the clinical efficacy of sepsis within 3 days. There is no difference between the early treatment group and the control group in improving tissue ischemia and hypoxia and protecting renal function.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R459.7

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