亚低温环境下盐酸纳洛酮注射液治疗重症颅脑损伤的临床研究

发布时间：2019-03-05 10:01

【摘要】：目的观察亚低温环境下盐酸纳洛酮注射液治疗重症颅脑损伤的临床疗效及安全性。方法 162例重症颅脑损伤患者随机分为对照组及试验组,各81例。对照组给予常规治疗+亚低温治疗,试验组在对照组治疗的基础上,给予盐酸纳洛酮注射液0.3 mg·kg~(~(-1))·d~(~(-1))持续静脉滴注,qd。2组均持续治疗7 d。比较2组患者治疗前后血清基质金属蛋白酶-9(MMP-9)、S100蛋白(S100-B)水平,及治疗的有效率和安全性。结果治疗后,试验组和对照组的总有效率分别为82.72%(67/81例)和67.91%(55/81例),差异有统计学意义(P0.05)。治疗后,对照组和试验组患者血清MMP-9分别为(38.64±5.42),(24.48±3.41)μg·mL~(~(-1));S100-B水平分别为(0.98±0.14),(0.15±0.05)μg·L~(~(-1)),差异均有统计学意义(均P0.05)。对照组的药物不良反应有胃肠道反应、肝肾功能异常,药物不良反应的发生率为11.11%(9/81例);试验组的药物不良反应有胃肠道反应、肝肾功能异常,药物不良反应的发生率为7.41%(6/81例)。2组患者药物不良反应发生率比较,差异无统计学意义(P0.05)。结论低温环境下盐酸纳洛酮治疗能够显著降低重症颅脑损伤患者的血清MMP-9及S100-B水平,提高临床疗效,且安全性较高。
[Abstract]:Objective To observe the clinical effect and safety of naloxone hydrochloride injection in the treatment of severe head injury. Methods 162 patients with severe head injury were randomly divided into control group and test group. On the basis of the treatment of the control group, the control group was treated with the conventional treatment plus sublow temperature, and the experimental group was given a continuous infusion of the naloxone hydrochloride injection of 0.3 mg 路 kg-(~ (-1)) 路 d ~ (-1)) on the basis of the treatment of the control group, and the treatment group was treated for 7 days in the qd.2 group. The serum matrix metalloproteinase-9 (MMP-9) before and after the treatment was compared in the 2 groups. S100 protein (S100-B), and the efficiency and safety of treatment. Results The total effective rate of the test group and the control group was 82.72% (67/81) and 67.91% (55/81), respectively. The levels of MMP-9 in the control group and the test group were (38.64-5.42), (24.48-3.41) and (-(-1)), respectively. The levels of S100-B were (0.98-0.14), (0.15-0.05). The adverse reaction of the control group had gastrointestinal reaction, abnormal liver and kidney function, and the rate of adverse drug reaction was 11.11% (9/81). The adverse reaction of the drug in the test group had gastrointestinal reaction, and the liver and kidney function was abnormal. The incidence of adverse drug reactions was 7.41% (6/81). There was no significant difference in the incidence of adverse drug reactions in group 2 (P0.05). Conclusion The treatment of naloxone hydrochloride in low-temperature environment can significantly reduce the serum MMP-9 and S100-B levels in the patients with severe head injury, improve the clinical curative effect, and have higher safety.
【作者单位】：张家港市第一人民医院神经外科;江苏省人民医院神经外科;
【基金】：江苏省2011年六大才人高峰基金资助项目(100)
【分类号】：R651.15

【相似文献】