丹参川芎嗪注射液对急性颅脑损伤患者炎症因子的影响

发布时间：2019-03-26 14:50

【摘要】：目的观察丹参川芎嗪注射液对急性颅脑损伤患者炎症因子的影响。方法将82例急性颅脑损伤患者随机分为试验组和对照组,每组41例。对照组给予5%的葡萄糖注射液500 mL和常规治疗,每天1次;试验组在对照组的基础上给予丹参川芎嗪注射液5 mL,每天1次,静脉滴注,2组疗程均为7 d。观察2组患者治疗前后的肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、血流动力学、日常生活能力(ADL)评分、神经功能评分变化。结果治疗后,试验组TNF-α、IL-6、IL-8分别为(124.32±10.23),(154.43±10.34),(135.45±10.34)pg·mL~(-1);对照组分别为(156.43±11.43),(183.32±8.54),(189.34±14.32)pg·mL~(-1),2组比较,差异均有统计学意义(均P0.05)。治疗后,试验组的纤维蛋白原为(3.05±0.43)g·L~(-1),微循环滞留时间为(24.43±2.32)s,红细胞变性系数为1.32±0.12;对照组分别为(3.47±0.48)g·L~(-1),(27.56±2.84)s,1.08±0.11,差异均有统计学意义(均P0.05)。治疗后,试验组神经功能评分为(10.43±1.32)分,对照组为(15.33±1.67)分;试验组ADL评分为(63.54±1.02)分,对照组为(53.43±2.16)分,差异均有统计学意义(均P0.05)。试验组出现轻微皮疹1例,对照组未发现药物不良反应,2组药物不良反应率差异无统计学意义(P0.05)。结论丹参川芎嗪注射液能明显降低急性颅脑损伤患者的TNF-α、IL-6、IL-8水平,对改善患者的临床症状临床疗效良好,安全性高。
[Abstract]:Objective to observe the effect of salvia miltiorrhiza ligustrazine injection on inflammatory factors in patients with acute craniocerebral injury. Methods 82 patients with acute craniocerebral injury were randomly divided into test group and control group, 41 cases in each group. The control group was given 5% glucose injection 500 mL and routine treatment once a day, and the experimental group was given salvia miltiorrhiza ligustrazine injection 5 mL, once a day on the basis of the control group, the course of treatment in both groups was 7 d. The changes of tumor necrosis factor-伪 (TNF- 伪), interleukin-6 (IL-6), interleukin-8 (IL-8), hemodynamics, activity of daily living (ADL) score and neurological function score were observed before and after treatment in two groups. Results after treatment, the TNF- 伪 and IL-6,IL-8 of the experimental group were (124.32 卤10.23), (154.43 卤10.34), (135.45 卤10.34) pg 路mL ~ (- 1), respectively. The control group was (156.43 卤11.43), (183.32 卤8.54), (189.34 卤14.32) pg 路mL ~ (- 1), the difference was statistically significant (P 0.05). After treatment, the fibrinogen of the experimental group was (3.05 卤0.43) g 路L ~ (- 1), the retention time of microcirculation was (24.43 卤2.32) s, and the erythrocyte denaturation coefficient was 1.32 卤0.12; The control group was (3.47 卤0.48) g 路L ~ (- 1), (27.56 卤2.84 s, 1.08 卤0.11 (P 0.05). After treatment, the score of neurologic function was (10.43 卤1.32) in the experimental group and (15.33 卤1.67) in the control group. The ADL score of the test group was (63.54 卤1.02), and that of the control group was (53.43 卤2.16), the difference was statistically significant (P 0.05). There was no adverse drug reaction in the control group, and there was no significant difference in the adverse drug reaction rate between the two groups (P0.05). Conclusion Salvia miltiorrhiza ligustrazine injection can significantly reduce the levels of TNF- 伪 and IL-6,IL-8 in patients with acute craniocerebral injury, and can improve the clinical symptoms of patients with good clinical efficacy and high safety.
【作者单位】：杭州师范大学附属医院急诊科;
【基金】：杭州市科技局基金资助项目(20150733Q18)
【分类号】：R651.15

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