急性缺血性脑卒中患者脑白质病变与HbA1c水平的相关性分析

发布时间：2019-04-13 19:30

【摘要】：目的探讨初发急性缺血性脑卒中患者脑白质病变(cerebral white matter disease,WMD)的血管危险因素,及其与Hb A1c水平的相关性。方法纳入初发急性缺血性脑卒中患者,收集患者入院当时及入院后第2天的影像学资料和血生化检查资料,根据患者WMD分级标准将患者分为4级。详细记录患者的人口统计学资料,血管危险因素和FLAIR序列显示的WMD影像资料并进行比较和分析。结果共纳入512例首发急性缺血性脑卒中患者,其中男性320(62.5%)例,460(89.8%)例患者存在WMD,其中无WMD患者52例,轻度WMD患者205例,中度WMD患者139例,重度WMD患者116例。单变量分析显示,高龄、高血压、肾小球滤过率降低,Hb A1c水平降低,男性与WMD呈正相关(P0.05)。进一步的多变量Logistic回归发现,高龄、高血压和Hb A1c增高是WMD的独立危险因素。结论急性缺血性脑卒中患者Hb A1c增高是WMD的独立危险因素之一。
[Abstract]:Objective to investigate the vascular risk factors of white matter disease (cerebral white matter disease,WMD) in patients with primary acute ischemic stroke and its correlation with the level of Hb A1c. Methods the data of imaging and blood biochemical examination were collected from the patients with acute ischemic stroke at the time of admission and the second day after admission. The patients were divided into 4 grades according to the criteria of WMD classification. The demographic data, vascular risk factors and WMD data of FLAIR sequence were recorded and compared and analyzed. Results A total of 512 patients with first-episode acute ischemic stroke were enrolled, including 320 males (62.5%), 460 patients (89.8%) with WMD, 52 patients without WMD, 205 patients with mild WMD, and 139 patients with moderate WMD. There were 116 patients with severe WMD. Univariate analysis showed that old age, hypertension, glomerular filtration rate (GFR) and Hb A1c level decreased, and there was a positive correlation between male and WMD (P0.05). Further multivariate Logistic regression revealed that older age, hypertension and increased Hb A1c were independent risk factors for WMD. Conclusion the increase of Hb A1c in patients with acute ischemic stroke is one of the independent risk factors of WMD.
【作者单位】：海口市人民医院神经内科;
【分类号】：R743.3

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