普罗布考联用丁苯酞治疗急性脑梗死的临床观察

发布时间：2019-06-06 11:37

【摘要】：目的:探讨普罗布考联用丁苯酞治疗急性脑梗死的临床疗效及安全性。方法:172例急性脑梗死患者按随机数字表法分为观察组与对照组,各86例。两组患者均接受急性脑梗死常规治疗,包括发病4.5 h内溶栓、抗血小板聚集、降颅压、营养支持、强化降脂等,并及时处理基础疾病。对照组患者在此基础上给予普罗布考片口服,每次0.5 g,bid。观察组患者在对照组治疗基础上加用丁苯酞氯化钠注射液,每次100 ml,bid,分别于每天9:00、17:00静脉滴注,50~90 min内滴注完毕。两组均持续治疗2周。观察两组患者治疗前后脂质代谢指标和血清S100β蛋白、神经元特异性烯醇化酶(NSE)、超敏C反应蛋白(hs-CRP)水平,美国国立卫生院卒中量表(NIHSS)评分,临床疗效及不良反应发生情况。结果:与治疗前比较,两组患者治疗后的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均显著下降,高密度脂蛋白胆固醇水平均显著上升,且观察组患者的TG、TC、LDLC水平下降得更明显,差异均有统计学意义(P0.05);两组患者治疗后的血清S100β蛋白、NSE、hs-CRP水平及NIHSS评分均显著降低,且观察组患者的NSE水平及NIHSS评分降低得更明显,差异均有统计学意义(P0.05)。观察组患者的总有效率为89.5%,显著高于对照组的62.8%,差异有统计学意义(P0.05)。两组患者治疗期间均未见明显不良反应发生,亦未见肝肾功能、凝血功能和心电图有明显变化。结论:普罗布考联用丁苯酞能够有效改善急性脑梗死患者的脂质代谢,降低血清NSE水平,对患者神经功能的早期恢复具有积极作用。
[Abstract]:Objective: to investigate the clinical efficacy and safety of propucol combined with butylphthalide in the treatment of acute cerebral infarction. Methods: 172 patients with acute cerebral infarction were randomly divided into observation group (n = 86) and control group (n = 86). The patients in both groups received routine treatment of acute cerebral infarction, including thrombolysis within 4.5 hours, antiplatelet aggregation, intracranial pressure reduction, nutritional support, enhanced lipid reduction, and timely treatment of basic diseases. On this basis, the patients in the control group were given Probucol tablets 0.5 g each time. The patients in the observation group were treated with sodium butylphthalein chloride injection on the basis of treatment in the control group. The patients in the observation group were injected intravenously at 9: 00, 17: 00 and 50: 90 min each time, respectively. Both groups were treated continuously for 2 weeks. The levels of lipid metabolism, serum S100 尾 protein, neuron-specific enolase (NSE), sensitive C-reactive protein (hs-CRP) and (NIHSS) score of National Hospital Stroke scale were observed before and after treatment in the two groups. Clinical efficacy and adverse reactions. Results: compared with before treatment, the total cholesterol (TC), (TC), low density lipoprotein cholesterol (LDL-C) level of triacylglycerol (TG), was significantly decreased and the level of high density lipoprotein cholesterol was significantly increased in both groups after treatment. The TG,TC,LDLC level of the patients in the observation group decreased more significantly, the difference was statistically significant (P 0.05). After treatment, the serum S100 尾 protein, NSE,hs-CRP level and NIHSS score were significantly decreased in the two groups, and the NSE level and NIHSS score in the observation group were significantly lower than those in the observation group (P 0.05). The total effective rate of the observation group was 89.5%, which was significantly higher than that of the control group (62.8%) (P 0.05). There were no obvious adverse reactions, no significant changes in liver and kidney function, coagulation function and electrocardiogram during treatment in both groups. Conclusion: propucol combined with butylphthalide can effectively improve lipid metabolism, decrease serum NSE level and play a positive role in the early recovery of neurological function in patients with acute cerebral infarction.
【作者单位】：新乡医学院第一附属医院药剂科;新乡医学院第一附属医院神经内科;
【分类号】：R743.33

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