丁苯酞注射液治疗老年急性脑梗死患者的疗效及其对脑血流动力和脑血管储备能力的影响
发布时间：2019-07-29 16:30
【摘要】：目的:探讨丁苯酞注射液治疗老年急性脑梗死(ACI)患者的疗效及其对脑血流动力和脑血管储备能力(CVR)的影响,阐明丁苯酞对ACI患者的药理作用机制。方法:选取100例老年ACI患者作为研究对象,按入院病例号的单、双号将其分为观察组和对照组,每组各50例。对照组患者给予常规治疗方法进行治疗,观察组患者在常规治疗方案的基础上加用丁苯酞注射液进行治疗。观察2组患者治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、双侧大脑中动脉(MCA)的峰流速(Vp)、平均流速(Vm)及差值(DVp、DVm)等脑血流动力学指标和脉动指数(PI)以及CVR,并进行比较;对2组患者的临床疗效进行评价和比较。结果:治疗后观察组患者NIHSS评分明显低于对照组(t=15.420,P0.05),观察组患者疗效分布和临床有效率均优于对照组(U=2.225,χ~2=5.005,P0.05);观察组患者治疗后Vp和Vm明显高于对照组(t=10.819,t=7.259,P0.05),而DVp和DVm明显低于对照组(t=16.348,t=19.055,P0.05);观察组患者治疗后的CVR明显高于对照组(t=6.884,P0.05),PI明显低于对照组(t=4.979,P0.05)。结论:丁苯酞注射液可有效纠正ACI患者的脑血流动力异常,提升机体稳定脑血管灌注量的能力,改善ACI患者的神经功能缺损症状,提高临床疗效。
[Abstract]:Objective: to investigate the efficacy of butylphthalide injection in the treatment of elderly patients with acute cerebral infarction (ACI) and its effect on cerebral hemodynamics and cerebral vascular reserve capacity (CVR), and to elucidate the pharmacological mechanism of butylphthalide on ACI patients. Methods: 100 elderly patients with ACI were divided into observation group (n = 50) and control group (n = 50) according to the single and double number of admission cases. The patients in the control group were treated with routine treatment, while those in the observation group were treated with butylphthalide injection on the basis of routine treatment. The (NIHSS) score of National Institutes of Health Stroke scale, the peak velocity (Vp), mean velocity (Vm) and difference (DVp,DVm) of bilateral middle cerebral artery (MCA), pulse index (PI) and CVR, were observed and compared between the two groups before and after treatment, and the clinical efficacy of the two groups was evaluated and compared. Results: after treatment, the NIHSS score of the observation group was significantly lower than that of the control group (t 鈮，
本文编号：2520626
[Abstract]:Objective: to investigate the efficacy of butylphthalide injection in the treatment of elderly patients with acute cerebral infarction (ACI) and its effect on cerebral hemodynamics and cerebral vascular reserve capacity (CVR), and to elucidate the pharmacological mechanism of butylphthalide on ACI patients. Methods: 100 elderly patients with ACI were divided into observation group (n = 50) and control group (n = 50) according to the single and double number of admission cases. The patients in the control group were treated with routine treatment, while those in the observation group were treated with butylphthalide injection on the basis of routine treatment. The (NIHSS) score of National Institutes of Health Stroke scale, the peak velocity (Vp), mean velocity (Vm) and difference (DVp,DVm) of bilateral middle cerebral artery (MCA), pulse index (PI) and CVR, were observed and compared between the two groups before and after treatment, and the clinical efficacy of the two groups was evaluated and compared. Results: after treatment, the NIHSS score of the observation group was significantly lower than that of the control group (t 鈮，
本文编号：2520626
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