NLR、RDW联合MELD评分对慢加急性肝衰竭患者预后的评估价值

发布时间：2023-01-31 01:52

　　研究背景及目的慢加急性肝衰竭（ACLF）是一种以慢性肝病急性失代偿和高短期死亡率为特征的临床综合征。因为ACLF的存活率极低（28天死亡率:22%-77%）,根据预后对患者进行分层是至关重要的,以确定肝移植（LT）的紧迫性。虽然终末期肝病模型（MELD）是评估ACLF患者最广泛使用的方法,但它缺乏临床事件的指标,如腹水、低钠血症、肝肾综合征和其他并发症。随着近年来肝病新疗法的不断涌现,迫切需要开发新的指标,完善评价ACLF患者病情严重程度和预后的指标体系。红细胞分布宽度（RDW）是反映红细胞体积异质性程度的一个简单而廉价的参数,传统上用于实验室血液学鉴别诊断贫血。最近,RDW作为各种疾病如脓毒症、急性心肌梗死、心力衰竭、自身免疫性疾病和肝病的预后标志物而受到广泛关注。近年来,外周血中性粒细胞与淋巴细胞比值（NLR）作为全身炎症标志物的研究越来越多,特别是考虑到其通过常规血细胞计数快速、广泛和相对便宜的评估。NLR已被证明是各种实体肿瘤的独立预后因子,包括肺癌、结直肠癌、胰腺癌、乳腺癌、卵巢癌和胃癌。但是目前关于NLR、RDW联合MELD评分对ACLF预后的评估价值的研究较少,本文通过回... 

【文章页数】：65 页

【学位级别】：硕士

【文章目录】：
摘要
Abstract
主要英文缩略词表
引言
材料与方法
结果
讨论
结论
参考文献
综述 慢加急性肝功能衰竭的研究进展
    参考文献
个人简历及在校期间发表论文
致谢


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