不同妊娠期振动对SD大鼠子代空间学习记忆的影响

发布时间：2018-01-28 22:40

本文关键词： 妊娠期振动 Barnes迷宫空间学习记忆能力　出处：《中国儿童保健杂志》2014年09期 　论文类型：期刊论文

【摘要】：目的探讨不同妊娠期振动对大鼠子代空间学习记忆的影响。方法分别在SD大鼠妊娠的1~7d、8~14d、15~21d施加强弱交替的振动刺激,在子鼠60d使用Barnes迷宫测试其空间学习记忆能力,比较各组间空间学习记忆的差异。结果学习过程:1)探索路程:妊娠早期振动组在第4天,妊娠中期在第1天,妊娠晚期在第1天高于对照组,妊娠晚期在第2、3天低于对照组(P0.05);2)探索平均速度:妊娠早期在第2天,妊娠中期在第1、2天,妊娠晚期在第1、2、3、7、8天均低于对照组(P0.05);3)错误探索时间:妊娠早期在第1、3、4、7、8天,妊娠中期在第3、4、5、8天高于对照组,妊娠晚期在第2、6天低于对照组(P0.05);4)首次探索目标洞潜伏期:妊娠中期在第5天高于对照组(P0.05)。记忆过程:妊娠早期振动组的错误探索时间明显高于对照组(Mann-Whitney U=43.00,P=0.000),妊娠晚期振动组的探索路程(Mann-Whitney U=150.00)、平均速度(Mann-Whitney U=150.00)和错误探索时间(Mann-Whitney U=164.50)明显低于对照组(P0.05或0.01)。结论妊娠早期振动损害子代的空间学习记忆能力,妊娠晚期振动可能促进子代的空间学习记忆能力,而妊娠中期仅损害子代的空间学习能力。
[Abstract]:Objective to investigate the effects of vibration during pregnancy on spatial learning and memory of rat offspring. The spatial learning and memory abilities were tested by Barnes maze on the 60th day. Results the learning process: 1) explore the distance: the vibration group of early pregnancy was on the 4th day. In the second trimester of pregnancy, it was higher on the first day, higher in the third trimester than in the control group, and lower in the third trimester than that in the control group (P 0.05). 2) the average speed of exploration was lower in the first trimester of pregnancy than in the control group on the 2nd day, the second day in the second trimester, the second day in the second trimester and the 78th day in the third trimester of pregnancy. 3) the time of error exploration: in the first trimester of pregnancy, in the first trimester of pregnancy, in the third trimester, in the third trimester, it was higher than that in the control group, and in the second trimester it was lower than that in the control group (P 0.05). 4) the latency of target hole was significantly higher in the second trimester of pregnancy than that in the control group on the 5th day. Memory process: the time of error exploration in the vibration group of early pregnancy was significantly higher than that in the control group (4). Mann-Whitney UM 43.00. P0. 000, Mann-Whitney U150.00in the third trimester vibration group. The average speed of Mann-Whitney U150.00) and the time of error detection were significantly lower than those of the control group (P < 0.05). Conclusion Vibration in early pregnancy can damage the spatial learning and memory ability of offspring. The vibration in the third trimester may promote the spatial learning and memory ability of the offspring, while the second trimester of pregnancy will only damage the spatial learning ability of the offspring.
【作者单位】：中山大学公共卫生学院妇幼卫生学系;
【基金】：广东省大学生创新训练项目(1055812297) 中山大学医科2012年学生业余科研项目(中大医教〔2012〕29号,No.49) 中山大学实验室开放基金(中大设备[2013]6号,No.KF201310) 2013年中山大学学生暑期科研项目(中大医教[2013]62号,No.36)
【分类号】：R749.5
【正文快照】： 应激(stress)是指有机体在生理或心理上受到威胁时出现的一种非特异的身心紧张状态,可分为生理应激和心理应激[1]。应激对机体的影响因其自身的强度和频率、发生的时间、应对策略的不同而不同。一般认为适度强度和频率的应激对机体是有益的,应激发生在机体相对不应期对机体影

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