频域OCT技术用于早期检测阿尔兹海默症患者黄斑区视网膜厚度改变的研究

发布时间：2018-01-28 23:08

本文关键词： 光学相干断层扫描技术阿尔兹海默病视网膜　出处：《实用医学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨光学相干断层扫描仪(OCT)技术用于检测阿尔兹海默病(AD)患者视网膜神经节细胞复合体和外层视网膜厚度改变的科学性和可靠性。方法:选取AD患者28例,正常志愿者30例。用OCT技术测量所有研究对象黄斑区上、下方视网膜神经节细胞复合体和外层视网膜的厚度,用简单精神状态检查(MMSE)进行评分,同时采集眼压,纵轴长度的数据。结果:OCT结果显示,AD患者黄斑区视网膜神经神经节细胞复合体较正常对照组薄,差异具有统计学意义,而外层视网膜厚度差异没有统计学意义,神经节细胞复合体的厚度与MMSE分值具有一定相关性,而与眼压之间没有明显相关性。结论:OCT技术能够检测出AD患者视网膜变薄,并且与患者疾病进展的程度相关,可用于早期筛查AD患者。
[Abstract]:Objective: to investigate the application of optical coherence tomography (Oct) in the detection of Alzheimer's disease (AD). The changes of retinal ganglion cell complex and outer retinal thickness in patients were scientific and reliable. Methods: 28 patients with AD were selected. The thickness of retinal ganglion cell complex and outer retina were measured by OCT technique in 30 normal volunteers. MMSE (simple mental state examination) was used to score and collect the data of IOP and length of longitudinal axis. Results: Oct results showed. In AD patients, the retinal ganglion cell complex in the macular area was thinner than that in the normal control group, and the difference was statistically significant, but there was no significant difference in the thickness of the outer retina. The thickness of ganglion cell complex was correlated with MMSE score, but not with intraocular pressure. Conclusion the retinal thinning of AD patients can be detected by using the technique of Oct. And it is related to the degree of disease progression and can be used for early screening of AD patients.
【作者单位】：武汉大学人民医院眼科;
【分类号】：R749.16;R770.4
【正文快照】： 在各种导致痴呆的因素中,AD是最常见的原因之一。AD患者通常表现为认知功能障碍和行为损害,其特征病理变化是:脑组织内神经元丢失,神经元纤维缠结和淀粉样蛋白在细胞外沉积[1]。AD的发病率与年龄关系密切,随着老龄化社会的到来,AD的发病率也随之增高,因此引起了研究人员的广泛

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