龙生蛭胶囊联合西药治疗气虚血瘀型血管性痴呆48例临床观察

发布时间：2018-02-25 02:12

  本文关键词： 血管性痴呆 龙生蛭胶囊 气虚血瘀 血清SB蛋白 人可溶性白细胞分化抗原配体　出处：《中医杂志》2014年16期 　论文类型：期刊论文

【摘要】：目的观察龙生蛭胶囊联合西药治疗气虚血瘀型血管性痴呆(VaD)疗效及机制。方法轻度VaD患者80例,按3∶2的比例随机分为治疗组48例与对照组32例。两组患者除基本治疗外,治疗组同时给予龙生蛭胶囊每次2.0g口服,每日3次;对照组给予奥拉西坦胶囊每次0.8g口服,每日3次,两组疗程均为6个月。观察两组患者治疗前后简易智能状态量表(MMSE)、日常生活能力(ADL)、中医证候积分和血清S100B蛋白、人可溶性白细胞分化抗原40配体(SCD40L)的变化。结果患者中医证候疗效治疗组总有效率85.42%,对照组为62.50%,治疗组优于对照组(P0.05)。治疗后治疗组除语言积分外,其他各项均较治疗前明显提高(P0.05),对照组定向积分较治疗前明显提高(P0.05),其他各项积分与治疗前比较差异无统计学意义(P0.05)。治疗后治疗组回忆积分及总积分较对照组明显提高(P0.05);两组治疗后计算、识记、定向与语言积分比较差异均无统计学意义(P0.05)。治疗组治疗后躯体性日常生活能力积分较治疗前和同期对照组降低明显(P0.05),两组ADL、工具性日常生活能力积分治疗前后以及两组治疗后差异无统计学意义(P0.05)。两组中医证候积分治疗后均较治疗前降低(P0.05或P0.01),治疗组降低更为明显(P0.05)。两组患者血清S100B和SCD40L水平治疗后均较治疗前降低,治疗组降低更加明显(P0.01)。结论龙生蛭胶囊能联合西药治疗气虚血瘀型血管性痴呆,其作用机制可能与其抗脑组织损伤和炎性反应有关。
[Abstract]:Objective to observe the efficacy and mechanism of Longshengzhi capsule combined with western medicine in treating vascular dementia with Qi deficiency and blood stasis. Methods 80 patients with mild VaD were randomly divided into treatment group (n = 48) and control group (n = 32). The treatment group was given 2.0 g Longshengzhi capsule three times a day, while the control group was given 0.8 g olaxetam capsule three times a day. The two groups were treated for 6 months. MMSE, ADL, TCM syndrome score and serum S100B protein were observed before and after treatment. Results the total effective rate of the treatment group was 85.42, and that of the control group was 62.50. The treatment group was superior to the control group (P 0.05). The other items were significantly higher than those before treatment, the directional integral of the control group was significantly higher than that of the control group, and there was no significant difference between the other scores and that before treatment. After treatment, the recall score and total integral in the treatment group were significantly higher than those in the control group. After treatment, the two groups were calculated, Memorization, The scores of somatic ADL after treatment in the treatment group were significantly lower than those in the control group and before and after treatment. The ADL and instrumental ADL scores in the two groups were significantly decreased before and after treatment. The scores of ADL and ADL before and after treatment in the treatment group were significantly lower than those in the control group before and after treatment. There was no significant difference between the two groups after treatment (P 0.05). After treatment, the scores of TCM syndromes in the two groups were lower than those before treatment (P 0.05 or P 0.01), and the levels of serum S100B and SCD40L in the treatment group were significantly lower than those before treatment, and the levels of serum S100B and SCD40L in the treatment group were lower than those before treatment. Conclusion Longshengzhi capsule can be combined with western medicine to treat vascular dementia with deficiency of qi and blood stasis, and its mechanism may be related to its anti-brain injury and inflammatory reaction.
【作者单位】： 武汉市武昌医院;
【分类号】：R749.13
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本文编号：1532609