文拉法辛对高血压伴抑郁症患者外周血干细胞因子和炎性因子表达的影响

发布时间：2018-03-20 07:30

本文选题：文拉法辛　切入点：高血压　出处：《江苏医药》2014年16期 　论文类型：期刊论文

【摘要】：目的探讨文拉法辛对高血压伴抑郁症患者外周血中干细胞因子(SCF)及其受体(c-kit)、内皮素1(ET-1)和IL-6及血压的影响。方法 97例高血压伴抑郁症患者随机分为实验组(51例,给予文拉法辛+苯磺酸氨氯地平治疗)和对照组(46例,给予苯磺酸氨氯地平治疗)。随访12周,观察降压效果,检测治疗前后SCF/c-kit、ET-1和IL-6表达水平变化,比较两组收缩压(SBP)、舒张压(DBP)和汉密尔顿抑郁量表(HAMD)评分。结果与对照组比较,实验组治疗后SCF/c-kit略高,但ET-1和IL-6水平明显降低[(117.9±17.8)ng/L vs.(131.8±14.8)ng/L和(31.7±10.2)ng/L vs.(46.1±9.8)ng/L](P0.01)。治疗后,实验组SBP、DBP和HAMD评分均低于对照组(P0.05或P0.01)。结论合并抑郁的高血压患者应尽早进行抗抑郁治疗,可进一步降低血压及炎性因子水平,有利于对心血管系统的保护。
[Abstract]:Objective to investigate the effects of venlafaxine on the levels of stem cell factor (SCF), its receptors (c-kitt 1), endothelin 1 (et 1), IL-6 and blood pressure in the peripheral blood of patients with hypertension and depression. Methods 97 patients with hypertension and depression were randomly divided into experimental group (n = 51) and experimental group (n = 51). Patients were treated with venlafaxine benzenesulfonic acid amlodipine (n = 46) and control group (n = 46). All patients were followed up for 12 weeks to observe the antihypertensive effect and to detect the expression of SCF / c kitt ET-1 and IL-6 before and after treatment. Results compared with the control group, the scores of systolic blood pressure (SBP), diastolic blood pressure (DBP) and Hamilton depression scale (Hamd) were slightly higher, but the levels of ET-1 and IL-6 were significantly lower [117.9 卤17.8 ng / L vs.(131.8 卤14.8 ng / L and 31.7 卤10.2ng / L vs.(46.1 卤9.8 ng / L] P 0.01. The scores of SBP and HAMD in the experimental group were lower than those in the control group (P 0.05 or P 0.01). Conclusion the patients with hypertension complicated with depression should be treated with antidepressant therapy as soon as possible, which can further reduce the levels of blood pressure and inflammatory factors, which is beneficial to the protection of cardiovascular system.
【作者单位】：南京市江宁区第二人民医院;南京医科大学第一附属医院心内科;
【基金】：南京市江宁区科学技术局,国家可持续发展实验区建设工程(2013Ea17)
【分类号】：R544.1;R749.4

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