Addenbrooke改良认知评估量表在慢性肾脏病患者认知功能的应用

发布时间：2018-03-25 17:21

本文选题：慢性肾脏病　切入点：认知损伤　出处：《实用医学杂志》2017年05期

【摘要】：目的:探讨Addenbrooke改良认知评估量表(ACE-R)在慢性肾脏病(CKD)患者认知功能评估中的应用。方法:招募南京地区4家综合医院2014年3-7月肾内科门诊及住院治疗的临床确诊的CKD患者共205例,采用ACE-R评估其认知功能,并对结果进行比较分析。结果:(1)NC-NCDs组(89.18±4.80)、Mild-NCDs(77.28±5.80)组和Major-NCDs组(55.90±10.90)之间ACE-R水平相比差异有统计学意义(F=292.28,P0.01),组间两两比较差异有统计学意义(均P0.01);(2)ACE-R(AUC=0.944,P0.01)对Mild-NCDs患者的识别能力显著优于MMSE(AUC=0.777,P0.01);(3)ACE-R总分区别NC-NCDs和Mild-NCDs患者最佳截断值为83/84(敏感度88.00%,特异度85.90%,约登指数0.739),区别Mild-NCDs和Major-NCDs患者最佳截断值为71/72(敏感度89.70%,特异度96.10%,约登指数0.858)。结论:ACE-R对CKD患者认知损伤不同严重程度具有较好的区分能力,同时可有效识别早期轻度认知功能损伤,适合临床推广用于CKD患者认知功能的评估与研究。
[Abstract]:Objective: to investigate the application of Addenbrooke modified cognitive assessment scale (ACE-R) in the evaluation of cognitive function in patients with chronic kidney disease (CKD). Methods: 205 patients with CKD were recruited from 4 general hospitals in Nanjing from March to July 2014. The cognitive function was evaluated by ACE-R. Results compared with Major-NCDs group (55.90 卤10.90), there was a significant difference in ACE-R level between the two groups (P < 0.01). There was significant difference between the two groups (all P0.01ACE-RAUC 0.944P0.01). The recognition ability of Mild-NCDs patients was significantly better than that of MMSEC0.777P0.01P0.01ACE-3ACE-R. The best truncation value of differentiating NC-NCDs and Mild-NCDs patients is 83 / 84 (sensitivity 88.00, specificity 85.90), Yorden index 0.739 ~ (g), and differentiating Mild-NCDs and Major-NCDs patients the best truncation value is 71 / 72 (sensitivity 89.70, specificity 96.10, Jordan index 0.8580.Conclusion: 1. 0% ACE-R has different severity of cognitive impairment in CKD patients. Degree has a good ability to distinguish, At the same time, it can effectively identify early mild cognitive impairment, which is suitable for clinical application in the evaluation and study of cognitive function in patients with CKD.
【作者单位】：南京医科大学附属江宁医院神经内科;
【分类号】：R692;R749.2

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