老年抑郁症患者白细胞介素水平及意义

发布时间：2018-04-03 16:45

本文选题：抑郁症　切入点：细胞因子　出处：《中国老年学杂志》2014年24期

【摘要】：目的探讨老年抑郁症患者外周血白细胞介素(IL)2、-1β、-6、肿瘤坏死因子(TNF-α)水平变化及其意义。方法采用ELISA检测首发老年抑郁症患者44例(抑郁症组)、健康老年人36例(对照组)外周血IL-6、IL-2、IL-1β、TNF-α水平。结果抑郁症组IL-2、IL-1β、IL-6分别为(48.502±11.266)、(8.910±19.818)、(1.478±1.456)ng/L,与正常组〔(49.713±11.800)、(31.615±71.815)、(1.478±1.456)ng/L〕比较无显著差异;抑郁症组与正常组TNF-α分别为(5.095±4.661)、(2.227±2.036)ng/L,具有统计学意义(P0.01)。TNF-α相关系数0.297,P=0.008。老年抑郁症组IL-2、IL-1β、IL-6、TNF-αROC曲线下面积分别为0.479、0.384、0.505、0.671,P值分别为0.750、0.074、0.934、0.009。结论 TNF-α参与了老年抑郁症的发生和发展,TNF-α为老年抑郁症的免疫学标志之一。
[Abstract]:Objective to investigate the elderly patients with depression of peripheral blood interleukin 2 beta (IL), -1, -6, tumor necrosis factor alpha (TNF- alpha) level changes and significance. Methods to detect 44 cases of first-episode senile depression in patients with ELISA (depression group), 36 healthy elderly (control group) of peripheral blood IL-6, IL-2 IL-1, beta, TNF- alpha level. The depression group IL-2, IL-1 beta, IL-6 respectively (48.502 + 11.266), (8.910 + 19.818), (1.478 + 1.456) ng/L, and the normal group (49.713 + 11.800), (31.615 + 71.815), (1.478 + 1.456) ng/L compared. The differences between the depression group and normal group; the TNF- alpha were (5.095 + 4.661), (2.227 + 2.036) ng/L, with statistical significance (P0.01).TNF- a correlation coefficient of 0.297, P=0.008. of senile depression group IL-2, IL-1 IL-6, TNF- alpha beta, the area under the ROC curve were 0.479,0.384,0.505,0.671 and P respectively 0.750,0.074,0.934,0.009. conclusion TNF- participate the senile depression The occurrence and development of TNF- A is one of the immunological markers of senile depression.

【作者单位】：新疆维吾尔自治区人民医院临床心理科;新疆维吾尔自治区人民医院检验科;
【基金】：国家自然科学基金地区科学基金项目(81260212)
【分类号】：R749.4

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