慢性自身免疫性甲状腺炎与抑郁症关系的初步分析

发布时间：2018-04-03 17:13

本文选题：甲状腺抗体　切入点：甲状腺功能　出处：《大连医科大学》2014年硕士论文

【摘要】：目的：近年来慢性淋巴细胞性甲状腺炎的发病率、抑郁症的发病率均持续上升，相关资料提示我们慢性淋巴细胞性甲状腺炎与抑郁有共同的发病机制，他们存在关联，我们通过我院门诊就诊的患者进行分组，研究两者的发病情况。方法：选取在大连大学附属中山医院内分泌科门诊符合实验入选条件的患者，年龄范围选择能完成抑郁评分者，性别随机。将符合实验入选条件的病例按抗甲状腺抗体阳性和甲状腺功能正常和异常分为实验组和实验对照组，抗甲状腺抗体阴性和甲状腺功能正常的患者作为对照组。对所有入选研究对象的资料进行整理，记录年龄、性别、教育程度、职业、婚姻情况等。将收集到的病例按实验分组的标准分到各个组中，进行抑郁评分，抑郁评分的方法采用汉密顿抑郁量表统计。对各组抑郁评分和严重程度进行相关性分析。结果：1）年龄因素与正常对照组相比，实验组、实验对照组年龄小十余岁，两个实验组的平均年龄相差不大。2）性别因素与正常对照组相比，实验组男性居多。3）生活状态三组无统计学差异。4）职业情况从事教育、文职类工作的人数在三组中的分布比较接近，其他无明显规律。5）受教育程度两个实验组相对于正常对照组，受高等教育水平的人数接近并略高。6）甲状腺功能及抗甲状腺抗体水平与正常对照组相比，，实验组甲状腺抗体升高；与实验组相比，实验对照组，甲状腺功能升高，存在统计学差异（P＜0.01）。7）抑郁评分实验组和实验对照组明显高于对照组，有统计学差异（P＜0.01）。实验组与实验对照组的抑郁得分的平均分结果没有统计学差别（P＞0.05）。8）抑郁程度抑郁评分小于8时（表示为正常状态），正常对照组人数高于实验组和实验对照组，存在统计学差异（P＜0.01）；抑郁评分为8-20（轻度抑郁）和20-35（中度抑郁）时人数比例，对照组低于实验组和实验对照组，有统计学差异（P＜0.05），但两实验组差别不大。结论：通过资料分析，表明慢性自身免疫性甲状腺炎与抑郁症有关联，两者关联的主要因素是免疫功能障碍，但与是否有甲状腺功能异常关系不大。
[Abstract]:Objective: in recent years, the incidence of chronic lymphocytic thyroiditis rate, the incidence of depression increased continually, relevant information suggests that chronic lymphocytic thyroiditis and depression have a common pathogenesis, they are related, we through the clinic of our hospital patients were divided into two groups, the incidence of the two.
Methods: in Dalian University affiliated Zhongshan Hospital Department of Endocrinology outpatient department in accordance with the experimental conditions were selected, the age range of choice to complete depression scores, gender randomly selected condition. Meet the test cases according to anti thyroid antibodies and thyroid function of normal and abnormal divided into experimental group and experimental control group, negative anti thyroid antibodies and thyroid function normal patients as control group. All the selected research object data, record the age, gender, education, occupation, marital status and so on. The collected cases according to experimental group standards assigned to each group, depression score, depression score using the statistics method of Hamilton Depression Rating. The correlation analysis of each depression score and severity.
Results: 1) the age factor compared with normal control group, experimental group, experimental control group of age more than 10 years old, the average age of the two experimental groups had similar gender.2) compared with the normal control group, experimental group.3) male life no statistical difference between the three groups of.4) in the number of civilian occupation education. The work of the distribution in the three groups comparing to the other, no obvious rule.5) education in two experimental groups compared with normal control group, the number of higher education level is close to and slightly higher.6) thyroid function and anti thyroid antibody levels compared with normal control group, the experimental group increased compared with thyroid antibodies; the experimental group, experimental control group, thyroid function increased, there was significant difference (P < 0.01).7) depression score in experimental group and experimental control group was significantly higher than the control group, there was significant difference (P < 0.01). The experimental group and the experiment of According to the group average depression scores did not result in statistically significant difference (P > 0.05).8) depression depression score is less than 8 (expressed as normal), the number is higher than the normal control group experimental group and experimental control group, there was significant difference (P < 0.01); depression score was 8-20 (mild depression) and 20-35 (moderate depression) when the ratio of the number, the control group than in the experimental group and experimental control group, there was significant difference (P < 0.05), but the two experimental group difference.
Conclusion: through the analysis of data showed that associated with chronic autoimmune thyroiditis and depression, two main factors associated with immune dysfunction, but whether there is abnormal thyroid function has little relationship.

【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R581.4;R749.4

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