首发精神分裂症患者血清BDNF水平与认知功能的关系研究

发布时间：2018-04-03 18:24

本文选题：精神分裂症　切入点：脑源性神经营养因子　出处：《中国卫生检验杂志》2014年19期

【摘要】：目的探讨首发精神分裂症患者血清BDNF水平的变化与认知功能之间的关系。方法采用威斯康星卡片分类测验(WCST)、持续操作测验(CPT)和阳性及阴性症状量表(PANSS)分别评定70例首发精神分裂症患者和80例正常人群的执行功能和精神症状;采用酶联免疫法(ELISA)测定受试者血清BDNF水平。结果与对照组比较,患者组WCST的总应答数、持续性错误数、随机错误数均增加,完成分类数和CPT各项指标减少,血清BDNF水平降低,上述差异均有统计学意义(P0.01);相关分析表明WCST中总应答数、持续性错误、随机错误数与患者血清BDNF水平呈负相关,完成分类数和CPT各项指标与患者血清BDNF水平呈正相关(P0.01)。结论首发精神分裂症患者存在执行功能受损和血清BDNF水平下降,且其血清BDNF浓度与认知功能障碍程度呈正相关。
[Abstract]:Objective to investigate the relationship between the changes of serum BDNF level and cognitive function in patients with first-episode schizophrenia.Methods 70 patients with first episode schizophrenia and 80 normal controls were assessed by WCSTT, CPT and PANSS, respectively.The serum BDNF level was measured by enzyme linked immunosorbent assay (Elisa).Results compared with the control group, the total number of WCST responses, the number of persistent errors, the number of random errors increased, the number of complete classification and the indexes of CPT decreased, and the level of serum BDNF decreased in the patient group.The correlation analysis showed that the total response number, persistent error and random error number in WCST were negatively correlated with the serum BDNF level, and the complete classification number and the CPT indexes were positively correlated with the serum BDNF level of the patients.Conclusion there were impaired executive function and decreased serum BDNF level in patients with first-episode schizophrenia, and the serum BDNF level was positively correlated with the degree of cognitive impairment.
【作者单位】：康慈医院;
【分类号】：R749.3

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