中国人群白细胞介素-1α基因多态性与阿尔茨海默病易感性的关系
发布时间:2018-04-04 12:50
本文选题:Meta分析 切入点:阿尔茨海默病 出处:《中国老年学杂志》2014年23期
【摘要】:目的探索中国人群白细胞介素(IL)-1α基因第889位C→T突变(C889T)多态性与阿尔茨海默病(AD)的关系。方法采用固定效应模型或随机效应模型对符合条件的研究进行Meta分析。结果 AD患者1 915例,对照1 726例。基因模型T vs C、TT vs CC、TT+CT vs CC、TT vs CT+CC的OR值分别为1.13,1.95,1.11,1.85,95%CI=0.88~1.44,1.11~13.43,0.85~1.45,1.05~3.25。结论 IL-1αC889T多态性与AD的易感性相关。
[Abstract]:Objective to investigate the relationship between the polymorphism of interleukin-1 伪 (IL-1a) gene and Alzheimer's disease (AD) in Chinese population.Methods fixed effect model or random effect model were used to analyze the conformance.Results there were 1 915 AD patients and 1 726 controls.The OR values of CC in gene model T vs CCT TT vs CCT TT vs CCT TT vs CT were 1.131.95U 1.111.85C 95 CI 0.8813.4C 1.1113.43C 0.851.55C 1.05v 3.25.Conclusion IL-1 伪 C889T polymorphism is associated with AD susceptibility.
【作者单位】: 重庆市肿瘤研究所感染管理科;
【分类号】:R749.16
,
本文编号:1710021
本文链接:https://www.wllwen.com/yixuelunwen/jsb/1710021.html
最近更新
教材专著