脑脊液和血浆24S-羟基胆固醇水平与轻度认知障碍和阿尔茨海默症关系的Meta分析

发布时间：2018-04-18 13:21

本文选题：阿尔茨海默症 + 轻度认知障碍　；参考：《现代预防医学》2017年13期

【摘要】：目的系统评价脑脊液和血浆中24S-羟基胆固醇(24S-hydroxycholesterol,24S-OHC)水平与轻度认知障碍(Mild cognitive impairment,MCI)和阿尔茨海默症(Alzheimer’s disease,AD)的关系。方法全面检索Pubmed,Elseviser和EMBASE数据库中关于MCI和AD患者脑脊液和血浆24S-OHC水平变化的观察性研究,并进行文献质量评价和资料提取,Review Manager 5.2和Stata12.0对数据进行Meta分析。结果共有20篇文献纳入分析。Meta结果显示,MCI和AD患者脑脊液中24S-OHC水平都显著高于年龄匹配的健康对照组,合并效应量MD=1.18(95%CI=0.67~1.69,Z=4.54,P0.001)和MD=0.75(95%CI=0.34~1.17,Z=3.59,P0.001),差异均有统计学意义;而与健康对照组相比,MCI和AD患者血浆中的24S-OHC水平的meta分析合并效应量MD=-2.93(95%CI=-7.29~1.43,Z=1.32,P=0.19)和MD=1.42(95%CI=-3.61~6.45,Z=0.55,P=0.58),差异均无统计学意义。结论脑脊液中24S-OHC的水平显著增高可能作为早期预测MCI和AD风险的生物标志物,对于辅助早期预测及干预认知障碍具有重要意义;而血浆24S-OHC的水平与MCI和AD风险预测无显著相关性。
[Abstract]:Objective to systematically evaluate the relationship between the levels of 24S-hydroxycholesterol in cerebrospinal fluid (CSF) and plasma (24S-hydroxycholesterol 24S-OHCC) and mild cognitive impairment (mild cognitive impairment MCI) and Alzheimer's disease (ADD).Methods We searched the database of Pubmedus Elseviser and EMBASE to investigate the changes of cerebrospinal fluid (CSF) and plasma 24S-OHC levels in patients with MCI and AD, and evaluated the literature quality and extracted the data from Manager 5.2 and Stata12.0 for Meta analysis.Results A total of 20 articles were included in the analysis. Meta results showed that the levels of 24S-OHC in CSF of patients with MCI and AD were significantly higher than those of age-matched healthy controls.Compared with the healthy control group, the meta analysis of plasma 24S-OHC levels in patients with MCI and AD combined with MD-2.93-95 CIQ -7.29 ~ 1.43C ~ (-1.32C) 0.19) and MD-1.42C ~ (-3.61) ~ (6.45)% ~ 0.55P0.58 (P < 0.05), there was no significant difference between the two groups, and there was no significant difference between the two groups.Conclusion the increased level of 24S-OHC in cerebrospinal fluid may be used as a biomarker to predict the risk of MCI and AD in the early stage, and it is of great significance to assist in early prediction and intervention of cognitive impairment.There was no significant correlation between plasma 24S-OHC levels and risk prediction of MCI and AD.
【作者单位】：武汉科技大学医学院;武汉科技大学公共卫生学院;
【基金】：2014年中国营养学会营养科研基金——帝斯曼专项科研基金,2014-052(CNS-DSM)
【分类号】：R749.16

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