艾司西酞普兰治疗慢性心力衰竭合并抑郁伴或不伴焦虑的临床观察

发布时间：2018-05-29 19:01

本文选题：慢性心力衰竭 + 艾司西酞普兰　；参考：《中国药房》2015年12期

【摘要】：目的:观察艾司西酞普兰治疗慢性心力衰竭(CHF)合并抑郁伴或不伴焦虑的临床疗效和安全性。方法:将50例CHF合并抑郁伴或不伴焦虑患者随机均分为对照组和观察组。对照组患者给予原发病治疗、去除CHF诱因、限制饮食、口服CHF治疗药物等常规治疗;观察组患者在对照组治疗的基础上给予艾司西酞普兰片10 mg,口服,每日1次。两组患者疗程均为6个月。观察两组患者的临床疗效、治疗前后抑郁自评量表(SDS)评分、汉密尔顿抑郁量表(HAMD)评分、左心室射血分数(LVEF)、左心室短径缩短率(FS)及不良反应发生情况。结果:治疗后观察组患者总有效率显著高于对照组,差异有统计学意义(P0.05)。治疗后两组患者SDS评分、HAMD评分均显著低于同组治疗前,且观察组低于对照组;LVEF、FS均显著高于同组治疗前,且观察组高于对照组(P0.05)。两组患者不良反应发生率比较差异无统计学意义(P0.05)。结论:艾司西酞普兰可有效改善CHF合并抑郁伴或不伴焦虑患者的抑郁症状,提高心功能,且安全性较好。
[Abstract]:Objective: to observe the efficacy and safety of Escitalopram in the treatment of chronic heart failure (CHF) with or without anxiety. Methods: 50 CHF patients with or without anxiety were randomly divided into control group and observation group. The patients in the control group were treated with primary disease treatment, removing the inducement of CHF, limiting diet, oral CHF therapy and other routine treatment, while the patients in the observation group were given 10 mg of estalopram tablets once a day on the basis of the treatment in the control group. The course of treatment was 6 months. The clinical efficacy, the scores of self-rating depression scale (SDS), Hamilton depression scale (Hamd), left ventricular ejection fraction (LVEF), left ventricular short diameter shortening rate (LVEFN) and adverse events were observed. Results: the total effective rate in the observation group was significantly higher than that in the control group after treatment, and the difference was statistically significant (P 0.05). After treatment, the SDS score and Hamd score of the two groups were significantly lower than those of the control group before treatment, and those of the observation group were significantly higher than those of the control group before treatment, and that of the observation group were higher than those of the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Escitalopram can effectively improve the depressive symptoms of CHF patients with or without anxiety and improve the cardiac function.
【作者单位】：慈溪市人民医院药剂科;慈溪市人民医院ICU;
【分类号】：R749.4;R541.6

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