注意缺陷多动障碍儿童静息fMRI低频振幅与功能连接的研究

发布时间：2018-06-04 08:24

本文选题：注意缺陷多动障碍 + 静息态功能磁共振　；参考：《苏州大学》2012年硕士论文

【摘要】：目的：本研究采用静息态fMRI低频振幅算法结合注意缺陷多动障碍症状评分量表，探讨ADHD儿童静息自发脑活动与临床症状的关系；采用功能连接算法进行ADHD前扣带回的功能研究。方法：选取了学龄期ADHD混合型32例和年龄匹配的正常儿童30名。1、采用静息fMRI低频振幅（amplitude of frequency fluctuation，ALFF）作为测量指标，结合临床症状量表作相关分析。2、采用功能连接（functionalconnectivity，FC）作为测量指标，对比ADHD与正常儿童前扣带回（Anterior cingulatedcortex，ACC）的功能差别。结果：1、ADHD与正常对照组比较在右侧额上回、左侧额上回内侧、左额中回、左前扣带回ALFF偏低；在左侧眶额叶内侧、右侧楔叶、右侧枕中回、右侧小脑、颞中回及左侧旁中央小叶ALFF值偏高。ALFF与临床症状量表总分相关显著脑区为：左额上回内侧、右楔叶。2.与正常对照组比较，，ADHD的尾部位点与左辅助运动区、左侧眶额下叶、左侧岛叶；的FC增强；与右枕叶的FC降低。头部位点与右颞中回、左眶额下叶、左额上回内侧、右上前扣带回、左侧额中回的FC增强；与右侧额中回（工作记忆）、右侧小脑FC降低。结论：1、静息态fMRI低频振幅研究显示ADHD在静息状态的前额叶自发活动异常低下，某些功能相关脑区代偿增强；前额叶及楔叶的静息自发活动水平与ADHD的症状严重程度呈正相关。2、静息fMRI功能连接研究显示两组儿童均存在ACC尾部认知和头部情感的功能分离；ACC与默认网络的连接通路存在异常，ACC尾部与运动相关的脑区功能连接增强；作为执行功能通路节点的ACC的异常是ADHD关键脑区。
[Abstract]:Objective: to investigate the relationship between resting spontaneous brain activity and clinical symptoms in children with ADHD by using resting fMRI low frequency amplitude algorithm combined with attention deficit hyperactivity disorder (ADHD) symptom scale, and to study the function of ADHD anterior cingulate gyrus by functional connection algorithm. Methods: Thirty-two school-age ADHD mixed type and 30 age-matched normal children were selected. Rest fMRI low frequency amplitude of frequency structure was used as the measurement index, and clinical symptom scale was used as correlation analysis. The functional connectivity test was used as the measurement index. To compare the functional difference between ADHD and normal children. Results compared with the control group, ALFF in the right superior frontal gyrus, left middle frontal gyrus, left anterior cingulate gyrus and left anterior cingulate gyrus were lower than those in the control group, and in the medial orbital frontal lobe, right cuneate lobe, right middle occipital gyrus, right cerebellum, right cerebellar gyrus. The ALFF value of middle temporal gyrus and left paracentral lobule was higher. ALFF was significantly related to the total score of clinical symptom scale: left superior frontal gyrus medial, right cuneiform lobe. Compared with the control group, the tail site of ADHD and the left auxiliary motor area, the left orbital subfrontal lobe, the left insular lobe, the FC enhancement, and the FC of the right occipital lobe were decreased. The FC of right middle temporal gyrus, left orbital inferior frontal lobe, medial left superior frontal gyrus, right superior cingulate gyrus and left middle frontal gyrus were enhanced, but decreased with right middle frontal gyrus (working memory, right cerebellar gyrus). Conclusion the low-frequency amplitude study of fMRI in resting state showed that the spontaneous activity of ADHD in prefrontal lobe of resting state was abnormal and the compensatory effect of some functional related brain regions was enhanced. The level of spontaneous resting activity in prefrontal and cuneiform lobes was positively correlated with the severity of ADHD symptoms. The study of resting fMRI functional connection showed that there was a functional separation between ACC tail cognition and head emotion in both groups. There were abnormal ACC tail and motor related functional junctions in the approach. The abnormality of ACC, which is the node of executive pathway, is the key brain area of ADHD.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.94

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