遗忘型轻度认知障碍的记忆力与fMRI度中心性的相关性

发布时间：2018-06-05 11:33

本文选题：轻度认知障碍 + 静息态功能核磁共振　；参考：《中国老年学杂志》2017年07期

【摘要】：目的应用度中心性(DC)的分析方法,探讨遗忘型轻度认知障碍(aMCI)患者静息态功能核磁共振(RS-fMRI)脑网络的变化及其与aMCI患者记忆力减退的相关性。方法招募aMCI患者与正常老年人(HC组)各25例,采用简易精神状态检查量表(MMSE)和韦氏记忆量表(WMS-RC)评估参与者的整体认知功能和记忆力,同时采集RS-fMRI数据。使用DPABI软件进行数据预处理,严格质控,对两组DC值做两样本t检验,比较组间差异,找出差异脑区;并提取两组有显著差异的脑区DC值,与WMS-RC评分结果做相关分析。结果 aMCI患者右侧额中回、右侧角回、颞上回、双侧后扣带回、右侧扣带旁回等脑区DC值显著低于HC组;而在右侧舌回、左侧尾状核等脑区的DC值明显高于HC组。右侧额中回区DC值与WMS-RC图片记忆部分评分有中等强度的正相关(r=0.536 7)。结论 aMCI与正常老年人的脑功能节点DC存在差异,这种差异可能与情景记忆能力的下降有密切关系。
[Abstract]:Objective to investigate the changes of resting functional MRI RS-fMRI brain network in patients with amnesia mild cognitive impairment (MCI) and its correlation with memory loss in patients with aMCI. Methods A total of 25 patients with aMCI and 25 normal elderly with HC) were recruited to evaluate the overall cognitive function and memory of the participants with MMSE and WMS-RCrespectively. RS-fMRI data were collected at the same time. DPABI software was used for data preprocessing, strict quality control, two samples t test for DC value of two groups, to compare the difference between the two groups, to find out the difference brain area, and to extract the DC value of the brain region which had significant difference between the two groups, and to do the correlation analysis with the result of WMS-RC score. Results DC values in the right middle frontal gyrus, right angular gyrus, superior temporal gyrus, bilateral posterior cingulate gyrus and right paracarpal gyrus in aMCI patients were significantly lower than those in HC group, while DC values in right lingual gyrus and left caudate nucleus were significantly higher than those in HC group. There was a moderate positive correlation between DC value of right middle frontal gyrus and WMS-RC image memory score. Conclusion there is a difference between aMCI and DC of brain function node in normal old people, and this difference may be related to the decline of situational memory ability.
【作者单位】：福建中医药大学康复医学院;上海健康医学院健康信息技术与管理学院;
【基金】：国家自然科学基金面上项目(81574045)
【分类号】：R749.1

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