抑郁症相关的认知与情绪系统脑网络异常

发布时间：2018-06-05 16:18

本文选题：抑郁症 + 功能性磁共振成像　；参考：《科学通报》2017年22期

【摘要】：对周围的情境有正常的认知及产生相应的情绪对于人类社会交往有重要意义.与健康人群相比,抑郁个体却对情境有着减弱的认知加工及过强的情绪加工,这反映了大脑中认知及情绪网络功能上存在异常.以脑功能磁共振成像为研究手段,近年来对抑郁症脑机制的研究逐渐增多.这些研究在认知、情绪以及二者交互作用3个方面集中显示了额叶-边缘系统的功能改变.其中,情绪网络异常主要体现在杏仁核和脑岛,并涉及5-羟色胺转运体基因型与抑郁症之间的关系;认知网络异常主要体现在执行控制和默认网络;而抑郁症对二者交互作用的影响则主要体现在杏仁核和背外侧前额叶.了解归纳与抑郁症相关的认知和情绪脑网络异常能够为将来进一步揭示抑郁症发生的神经机制奠定基础,同时为更加深入的研究提供线索.
[Abstract]:It is important for human society to have a normal cognition of the surrounding situation and to produce the corresponding emotion. Compared with the healthy population, the depressed individuals have weakened cognitive processing and excessive emotional processing, which reflects the abnormal cognitive and emotional network function in the brain. Brain functional magnetic resonance imaging (fMRI) has been used to study the brain mechanism of depression in recent years. These studies focused on the functional changes in the frontal lobe-limbic system in three aspects: cognition, emotion, and interaction between the two. Among them, the abnormality of emotional network is mainly reflected in the amygdala and the brain island, and involves the relationship between serotonin transporter genotype and depression, the abnormality of cognitive network is mainly reflected in executive control and default network. The effects of depression on the interaction were mainly in amygdala and dorsolateral prefrontal lobe. Understanding the cognitive and emotional brain network abnormalities associated with depression can lay a foundation for further revealing the neurogenesis of depression and provide clues for further research.
【作者单位】：深圳大学情绪和社会认知科学研究所;
【基金】：国家自然科学基金(31671169,31530031) 深圳市高端人才科研启动基金(000099) 深圳大学新引进教师科研启动基金(201564)资助
【分类号】：R749.4

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