皮质下缺血性血管病患者神经精神症状临床特征

发布时间：2018-06-06 17:03

本文选题：皮质下缺血性血管病 + 轻度认知功能损害　；参考：《安徽医科大学学报》2014年04期

【摘要】：目的探讨皮质下缺血性血管病(SIVD)患者神经精神症状(NPS)的临床特征。方法采用中文版神经精神科问卷(CNPI)对50例正常健康老年人(NC)、101例SIVD患者[51例皮质下血管性轻度认知功能损害(SVMCI)及50例皮质下血管性痴呆(SVaD)患者]进行评定,比较各组间NPS的特征以及SVMCI和SVaD组之间NPS的发生率。结果 3组间CNPI总分有显著性差异,SVMCI组CNPI得分显著高于NC组且低于SVaD组,差异有统计学意义(P0.01)。SVaD组与NC组比较在激越、心境恶劣、焦虑、情感淡漠、易激惹、睡眠行为及进食障碍等症状得分方面差异有统计学意义(P0.05);SVMCI组与NC组比较在激越、情感淡漠、易激惹症状得分方面差异有统计学意义(P0.05)。从NPS发生率来看,SVaD组情感淡漠、睡眠行为、心境恶劣、进食障碍、异常行为发生率均显著高于SVMCI组,差异有统计学意义(P0.05)。结论 NPS是SIVD患者常见的临床症状;情感淡漠等症状是SIVD患者特征性的NPS表现,且随着认知损害的加重而愈加明显。
[Abstract]:Objective to investigate the clinical features of neuropsychiatric symptoms (NPS) in patients with subcortical ischemic vascular disease (SIVD). Methods A total of 101 patients with SIVD (51 patients with subcortical vascular mild cognitive impairment) and 50 patients with subcortical vascular dementia (SVaD) were assessed by CNPI, a Chinese version of neuropsychiatric questionnaire. The characteristics of NPS and the incidence of NPS between SVMCI and SVaD groups were compared. Results there was significant difference in the total scores of CNPI between the three groups. The CNPI score of SVMCI group was significantly higher than that of NC group and lower than that of SVaD group. The difference was statistically significant compared with NC group. There were significant differences in the scores of sleep behavior and eating disorders between SVMCI group and NC group in terms of agitation, apathy and irritability (P 0.05). The incidence of NPS in SVaD group was significantly higher than that in SVMCI group (P 0.05). Conclusion NPS is a common clinical symptom in patients with SIVD, and emotional apathy is a characteristic manifestation of NPS in patients with SIVD, and it becomes more and more obvious with the aggravation of cognitive impairment.
【作者单位】：安徽医科大学第一附属医院神经内科;
【基金】：安徽省教育厅自然科学基金重点项目(编号:KJ2011A170)
【分类号】：R749.1

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