丁苯酞联合脑安胶囊治疗急性腔隙性脑梗死后轻度认知功能障碍的临床观察

发布时间：2018-06-06 22:36

本文选题：丁苯酞 + 脑安胶囊　；参考：《时珍国医国药》2017年05期

【摘要】：目的探讨丁苯酞联合脑安胶囊治疗急性腔隙性脑梗死轻度认知功能障碍的临床疗效。方法以就诊的急性腔隙性脑梗死轻度认知功能障碍患者120例为研究对象,随机分为观察组、治疗A组和治疗B组各40例。A组给予急性脑梗塞常规治疗,B组常规治疗基础上给予丁苯酞胶囊,观察组常规治疗基础上给予丁苯酞胶囊及脑安胶囊口服,研究周期为4周。比较治疗前后3组患者的蒙特利尔智能评估(MOCA)量表、简易智能精神状态检查测量表(MMSE)评分比较及血清hs-CRP水平。结果组内比较:治疗4周后,三组患者认知功能评分及NIHSS评分均在较治疗前明显改善(P0.05)。组间比较:治疗4周后,观察组认知功能评分及NIHSS评分显著优于A组及B组,B组的认知功能评分及NIHSS评分明显优于A组,差异具有统计学意义(P0.05)。治疗1周及4周时,观察组的hs-CRP水平明显低于A组及B组,治疗B组的hs-CRP水平显著低于治疗A组,差异均具有显著性(P0.05)。结论丁苯酞联合脑安胶囊治疗急性腔隙性脑梗死轻度认知功能障碍患者可以有效改善其临床预后,临床疗效显著。
[Abstract]:Objective to investigate the clinical efficacy of butylphthalide combined with Nao an Capsule in the treatment of acute lacunar cerebral infarction with mild cognitive impairment. Methods 120 patients with acute lacunar cerebral infarction with mild cognitive impairment were randomly divided into observation group, group A and group B were treated with 40.A groups for routine treatment of acute cerebral infarction, group B. On the basis of routine treatment, butylphthalide capsule was given, and the observation group was given oral phthalide capsule and brain an capsule orally on the basis of routine treatment. The study cycle was 4 weeks. The Montreal intelligence assessment (MOCA) scale of 3 groups of patients before and after treatment, the comparison of the simple intelligent mental state Checklist (MMSE) score and the level of serum hs-CRP were compared. After 4 weeks of treatment, the cognitive function score and the NIHSS score of the three groups were significantly improved (P0.05) before the treatment. After 4 weeks of treatment, the cognitive function score and the NIHSS score of the observation group were significantly better than those in the group A and the B group. The cognitive function score and the NIHSS score in the group B were significantly better than those in the A group. The difference was statistically significant (P0.05). 1 weeks and 4 of the treatment groups were treated. At the week, the level of hs-CRP in the observation group was significantly lower than that of the A group and the B group. The hs-CRP level in the treatment group was significantly lower than that of the treatment group A, and the difference was significant (P0.05). Conclusion butylphthalide combined with brain safety capsule can effectively improve the clinical prognosis of patients with acute lacunar cerebral infarction with mild cognitive impairment, and the clinical effect is significant.
【作者单位】：江汉大学附属武汉市六医院;
【分类号】：R749.13

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